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Home Recombinant Human Proteins All DPYD Proteins

DPYD (NM_000110) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP316374 Recombinant protein of human dihydropyrimidine dehydrogenase (DPYD), 20 ug (Larger pack size?) $680 In Stock
TA308200 Rabbit polyclonal antibody to DPYD (dihydropyrimidine dehydrogenase) $325 3-7 Days
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OriGene Data
Species:Human Expression Host:HEK293
Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC216374. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag:C-terminal MYC/DDK Predicted MW:111.2 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families: Druggable Genome
Protein Pathways: Pyrimidine metabolismbeta-Alanine metabolismPantothenate and CoA biosynthesisDrug metabolism - other enzymesMetabolic pathways
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_000101 RefSeq Size: 4451 RefSeq ORF: 3078
LocusID: 1806 Cytogenetic: 1p22  
Synonyms : DHP; DHPDHASE; DPD
Summary: The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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