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Home Recombinant Human Proteins All STAT6 Proteins

STAT6 (NM_003153) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP310065 Recombinant protein of human signal transducer and activator of transcription 6, interleukin-4 induced (STAT6), 20 ug (Larger pack size?) 680 In Stock
TA309960 Rabbit anti-STAT6 (Phospho-Tyr641) polyclonal antibody (Phospho-specific) $325 3 Weeks
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OriGene Data
Species:Human Expression Host:HEK293 cells
Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC210065. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag:C-terminal MYC/DDK Predicted MW:94 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families: Stem cell relevant signaling - DSL/Notch pathwayStem cell relevant signaling - JAK/STAT signaling pathwayES Cell Differentiation/IPSTranscription FactorsDruggable Genome
Protein Pathways: Jak-STAT signaling pathway
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_003144 RefSeq Size: 3993 RefSeq ORF: 2544
LocusID: 6778 Cytogenetic: 12q13  
Synonyms : D12S1644; IL-4-STAT; STAT6B; STAT6C
Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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