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Home Recombinant Human Proteins All E2F1 Proteins

E2F1 (NM_005225) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP308247 Recombinant protein of human E2F transcription factor 1 (E2F1), 20 ug (Larger pack size?) 680 In Stock
TA308764 Rabbit polyclonal antibody to E2F1 (E2F transcription factor 1) $325 In Stock
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Also for E2F1 (NM_005225)
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OriGene Data
Species:Human Expression Host:HEK293 cells
Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC208247. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag:C-terminal MYC/DDK Predicted MW:46.7 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families: Transcription FactorsDruggable Genome
Protein Pathways: Cell cyclePathways in cancerPancreatic cancerGliomaProstate cancerMelanomaMore Pathways >>
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_005216 RefSeq Size: 2486 RefSeq ORF: 1314
LocusID: 1869 Cytogenetic: 20q11.2  
Synonyms : E2F-1; RBAP1; RBBP3; RBP3
Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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