Promotion ends on May 1st.
Also for PIM1 (NM_002648)
|Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC205853
. Click on the TrueORF clone link to view cDNA and protein sequences.
||Predicted MW:||35.5 kDa|
|Purity:||> 80% as determined by SDS-PAGE and Coomassie blue staining|
|Concentration:||>50 ug/mL as determined by microplate BCA method|
|Buffer:||25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.|
||Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
||Protein KinaseES Cell Differentiation/IPSDruggable Genome
||Jak-STAT signaling pathwayAcute myeloid leukemia
||RefSeq Size: 2684
||RefSeq ORF: 942|
|Synonyms : PIM|
|Summary: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]. |
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**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich