FGG (NM_000509) Purified Human Protein

Species: Human Expression Host: Human 293HEK cells Expression cDNA Clone and Sequence Recombinant protein was produced with TrueORF clone, RC202770. Click on the TrueORF clone link to view cDNA and protein sequences. Tag: C-terminal MYC/DDK Predicted MW: 46.4 kDa Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining Mass Spec Validation: This protein has been positively validated by MS/MS by Dr. Robert Moritz at The Institute of Systems Biology. Concentration: >50 ug/mL as determined by microplate BCA method Buffer and Storage: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions. Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. Protein Families: Secreted ProteinTransmembraneDruggable Genome Protein Pathways: Complement and coagulation cascades

Protein Data

RefSeq: NP_000500	RefSeq Size: 1665	RefSeq ORF: 1314
LocusID: 2266	Cytogenetic: 4q28
Synonyms : fibrinogen, gamma chain; fibrinogen, gamma polypeptide; fibrinogen gamma chain
Summary: The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul

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Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-A as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-A as transfection-ready DNA • Myc-DDK-tagged ORF clone of Homo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-A as 200 ug transfection-ready DNA Related Lysate from OriGene • Transient overexpression lysate of fibrinogen gamma chain (FGG), transcript variant gamma-A Validated Antibodies • Rabbit monoclonal antibody against Fibrinogen gamma chain(clone EPR3085) • Rabbit monoclonal antibody against Fibrinogen gamma chain (clone EPR3084 ) • Purified FGG mouse monoclonal antibody,clone 3A7 • Purified FGG mouse monoclonal antibody,clone 4B8 • Carrier-free (BSA/glycerol-free) FGG mouse monoclonal antibody,clone 3A7 • Carrier-free (BSA/glycerol-free) FGG mouse monoclonal antibody,clone 4B8 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • FGG - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • FGG - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Fgg - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • FGG - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Fgg - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector

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Protein	Full Length Protein A domain of the protein Description of domain...
Tag	C-fusion N-fusion     Tag Description:
DNA or protein sequence of the final product
Preferred Expression Host	HEK293 E. coli Insect Cells Yeast
The main application with the purified protein	R&D reagent Cell-based Assay Animal Study Other, please specify:
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