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Home Recombinant Human Proteins All CTNNA1 Proteins

CTNNA1 (NM_001903) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP301766 Recombinant protein of human catenin (cadherin-associated protein), alpha 1, 102kDa (CTNNA1), 20 ug (Larger pack size?) 680
$398
2 Weeks
TA302443 Goat Polyclonal Antibody against Catenin alpha1 $325 3-7 Days
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OriGene Data
Species:Human Expression Host:HEK293 cells
Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC201766. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag:C-terminal MYC/DDK Predicted MW:99.9 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families: Druggable Genome
Protein Pathways: Adherens junctionTight junctionLeukocyte transendothelial migrationPathways in cancerEndometrial cancerArrhythmogenic right ventricular cardiomyopathy (ARVC)More Pathways >>
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_001894 RefSeq Size: 3778 RefSeq ORF: 2721
LocusID: 1495 Cytogenetic: 5q31.2  
Synonyms : CAP102
Summary: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. [UniProtKB/Swiss-Prot Function]
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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