Promotion ends on May 1st.
Also for RUNX1T1 (NM_175636)
|Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC200898
. Click on the TrueORF clone link to view cDNA and protein sequences.
||Predicted MW:||63 kDa|
|Purity:||> 80% as determined by SDS-PAGE and Coomassie blue staining|
|Concentration:||>50 ug/mL as determined by microplate BCA method|
|Buffer:||25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.|
||Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
||Pathways in cancerAcute myeloid leukemia
||RefSeq Size: 3362
||RefSeq ORF: 1704|
|Synonyms : AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2|
|Summary: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]. |
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact firstname.lastname@example.org
for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich