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Home Recombinant Human Proteins All POLE3 Proteins

POLE3 (NM_017443) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP300874 Recombinant protein of human polymerase (DNA directed), epsilon 3 (p17 subunit) (POLE3), 20 µg (Larger pack size?) 680
$398
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TA309812 Mouse Monoclonal DNA Polymerase epsilon Antibody (3C5.1) $325 3-7 Days
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OriGene Data
Species:Human Expression Host:HEK293 cells
Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC200874. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag:C-terminal MYC/DDK Predicted MW:16.7 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families:
Protein Pathways: Purine metabolismPyrimidine metabolismMetabolic pathwaysDNA replicationBase excision repairNucleotide excision repairMore Pathways >>
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_059139 RefSeq Size: 2185 RefSeq ORF: 444
LocusID: 54107 Cytogenetic: 9q33  
Synonyms : CHARAC17; CHRAC17; p17; YBL1
Summary: POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]. Transcript Variant: This variant (3) retains the first intron compared to variant 1. This variant is represented as non-coding due to the presence of several upstream ORFs that are predicted to interfere with translation of the longest ORF; translation of any these upstream ORFs renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support ERS025084, ERS025087 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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