OriGene Technologies, Inc.
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
Home TrueClone Aak1 Clone

Aak1 (NM_177762) Mouse cDNA Clone

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
MC222351 Aak1 (untagged) - Mouse AP2 associated kinase 1 (Aak1), transcript variant 2, (10ug), NM_177762.6, 10ug $1050 7 weeks
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
Add to Shopping Cart
OriGene Data
Vector:pCMV6 Entry QM Insert Size: 2637 Restriction Site: SgfI-MluI
Sequence Data: Fully Sequenced ORF         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reference Data
RefSeq: NM_177762.6, NP_808430
RefSeq Size: 19120 RefSeq ORF: 2637
Synonyms : 5530400K14Rik; 9630042K20; AU067724; AU067726; BC028270; C79663; D6Ertd245e; mKIAA1048; R75501
LocusID: 269774 Cytogenetic: 6 D1|6 37.75 cM
Summary: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. [UniProtKB/Swiss-Prot Function]

Transcript Variant: This variant (2) lacks an alternate exon in the 3' CDS, compared to variant 1. The resulting protein (isoform 2) is shorter when compared to isoform 1. COMPLETENESS: complete on the 3' end.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping


Inc 5000 Healthcare Company
All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title

Notice to Non-US Customers

ExclaimationWeb price and delivery time are for direct sales only.

Non-US customers are encouraged to contact our dedicated distributor network for quotes and streamlined ordering/delivery support.