Activation of the Ca2+-sensing receptor increases renal claudin-14 expression and urinary Ca2+ excretion Am J Physiol Renal Physiol, Mar 2013; 304: F761 - F769.
[Cldn14]
An SRF/miR-1 axis regulates NCX1 and Annexin A5 protein levels in the normal and failing heart Cardiovasc Res, Mar 2013; 10.1093/cvr/cvt042.
[JunD]
Betaglycan Alters NFB-TGFß2 Cross Talk to Reduce Survival of Human Granulosa Tumor Cells Mol. Endocrinol., Mar 2013; 27: 466 - 479.
[SMAD3]
Cathepsin B and uPAR regulate self-renewal of glioma-initiating cells through GLI-regulated Sox2 and Bmi1 expression Carcinogenesis, Mar 2013; 34: 550 - 559.
[cathepsin B]
Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Product Components:
The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials.
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
