OriGene - NR1I3 (NM_001077470) 3’-UTR clone in pMirTarget

NR1I3 (NM_001077470) 3’-UTR clone in pMirTarget

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Cat. No.

Description

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Availability

SC201079

3`UTR clone of nuclear receptor subfamily 1 group I member 3 (NR1I3) transcript variant 11 for miRNA target validation

$495.00

4 weeks *

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

OriGene TrueClone Data

Vector:	pMirTarget	Insert Size: 141	Restriction Site: SgfI-MluI
Sequence Data:	Insert Sequence
OTI Disclaimer:	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials.

Reference Data

RefSeq:	NM_001077470.1
Synonyms :	CAR; CAR1; MB67
Locus ID:	9970
Summary:	This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].