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Home Recombinant Human Proteins NACA Heavy-labeled protein

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NACA Mass Spec Standard

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Cat. No. Ref. ID Description Price Availability
PH325257 NM_001113202 NACA MS Standard C13 and N15-labeled recombinant protein (NP_001106673), 10 ug $1500 3 weeks
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Also for NACA (NM_001113202)
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OriGene Data
Expression Host:Human HEK293 cells Predicted MW:23.2 kDa
Expression TrueORF clone:RC225257 Protein Sequence: Sequence Link
Tag:C-terminal MYC/DDK * Anti-Myc/DDK antibody Protein family:
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:> 50 ug/ml as determined by BCA
Labeling Method:Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer and Storage:100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Protein Image
*: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

Reference Data
RefSeq: NP_001106673 RefSeq Size: RefSeq ORF: 648
Synonyms : HSD48; NACA1; skNAC
LocusID: 4666 Cytogenetic: 12q23-q24.1  
Summary: The protein encoded by this gene associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). NAC binds to nascent proteins as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. However, nascent proteins with an exposed signal peptide will not be bound by the encoded protein, enabling them to bind the SRP and enter the secretory pathway. This protein has been determined to be an IgE autoantigen in atopic dermatitis patients. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

 

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