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Home Recombinant Human Proteins VAV1 Heavy-labeled protein

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VAV1 Mass Spec Standard

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Cat. No. Ref. ID Description Price Availability
PH324806 NM_005428 VAV1 MS Standard C13 and N15-labeled recombinant protein (NP_005419), 10 ug $1500 3 weeks
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Also for VAV1 (NM_005428)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data
Expression Host:Human HEK293 cells Predicted MW:98.1 kDa
Expression TrueORF clone:RC224806 Protein Sequence: Sequence Link
Tag:C-terminal MYC/DDK * Anti-Myc/DDK antibody Protein family:
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:> 50 ug/ml as determined by BCA
Labeling Method:Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer and Storage:100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Protein Image
*: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

Reference Data
RefSeq: NP_005419 RefSeq Size: 2888 RefSeq ORF: 2538
Synonyms : VAV
LocusID: 7409 Cytogenetic: 19p13.2  
Summary: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].

 

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