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Home Recombinant Human Proteins HAAO Heavy-labeled protein

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HAAO Mass Spec Standard

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Cat. No. Ref. ID Description Price Availability
PH306273 NM_012205 HAAO MS Standard C13 and N15-labeled recombinant protein (NP_036337), 10 ug $1500 3 weeks
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Also for HAAO (NM_012205)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data
Expression Host:Human HEK293 cells Predicted MW:32.4 kDa
Expression TrueORF clone:RC206273 Protein Sequence: Sequence Link
Tag:C-terminal MYC/DDK * Anti-Myc/DDK antibody Protein family:
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:> 50 ug/ml as determined by BCA
Labeling Method:Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer and Storage:100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Protein Image
*: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

Reference Data
RefSeq: NP_036337 RefSeq Size: 1247 RefSeq ORF: 861
Synonyms : 3-HAO; HAO
LocusID: 23498 Cytogenetic: 2p21  
Summary: 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008].

 

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