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Home Recombinant Human Proteins ACKR1 Heavy-labeled protein

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ACKR1 Mass Spec Standard

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Specifications Related Products FAQs
Cat. No. Ref. ID Description Price Availability
PH304680 NM_002036 DARC MS Standard C13 and N15-labeled recombinant protein (NP_002027), 10 ug $1500 3 weeks
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Also for ACKR1 (NM_002036)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data
Expression Host:Human HEK293 cells Predicted MW:35.4 kDa
Expression TrueORF clone:RC204680 Protein Sequence: Sequence Link
Tag:C-terminal MYC/DDK * Anti-Myc/DDK antibody Protein family:
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:> 50 ug/ml as determined by BCA
Labeling Method:Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer and Storage:100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Protein Image
*: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

Reference Data
RefSeq: NP_002027 RefSeq Size: 1317 RefSeq ORF: 1011
Synonyms : CCBP1; CD234; DARC; Dfy; FY; GPD; GpFy; WBCQ1
LocusID: 2532 Cytogenetic: 1q23.2  
Summary: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. [UniProtKB/Swiss-Prot Function]

 

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