OriGene - NAT1 (NM_001160173) cDNA Clone

OriGene Data

Vector:	pCMV6-XL5	Insert Size:	Restriction Site:
Sequence Data:	Fully Sequenced ORF 5' Read Nucleotide Sequence
OTI Annotation:	This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:
Protein Pathways:	Caffeine metabolism Drug metabolism - other enzymes Metabolic pathways

Reference Data

RefSeq: NM_001160173.1, NP_001153645	RefSeq Size:	RefSeq ORF: 872
Synonyms : AAC1; MNAT; NAT-1; NATI
LocusID: 9	Cytogenetic: 8p22
Summary: This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]. Transcript Variant: This variant (4) lacks an alternate exon in the 5' UTR, compared to variant 1. This variant is transcribed from a promoter 11.8 kb upstream of the coding exon known as the P1, promoter 2, or NATb promoter. Variants 1-6 and 9 all encode the same isoform (a).

TrueClone Citations:

Extreme C-terminal sites are posttranslocationally glycosylated by the STT3B isoform of the OST, Shiteshu Shrimal, Steven F. Trueman, and Reid Gilmore, J. Cell Biol., Apr 2013; 201: 81 - 95. [CD40]

Cellular glutathione plays a key role in copper uptake mediated by human copper transporter 1, Edward B. Maryon, Shannon A. Molloy, and Jack H. Kaplan, Am J Physiol Cell Physiol, Apr 2013; 304: C768 - C779. [CSS]

B-cell Maturation Antigen Is a Promising Target for Adoptive T-cell Therapy of Multiple Myeloma, Robert O. Carpenter, Moses O. Evbuomwan, Stefania Pittaluga, Jeremy J. Rose, Mark Raffeld, Shicheng Yang, Ronald E. Gress, Frances T. Hakim, and James N. Kochenderfer, Clin. Cancer Res., Apr 2013; 19: 2048 - 2060. [BCMA ]

Retinoic Acid Receptor ß Stimulates Hepatic Induction of Fibroblast Growth Factor 21 to Promote Fatty Acid Oxidation and Control Whole-body Energy Homeostasis in Mice, Yu Li, Kimberly Wong, Kenneth Walsh, Bin Gao, and Mengwei Zang, J. Biol. Chem., Apr 2013; 288: 10490 - 10504. [FGF21 ]

Natriuretic Peptide Receptor-3 Gene (NPR3): Nonsynonymous Polymorphism Results in Significant Reduction in Protein Expression Because of Accelerated Degradation, Naveen L. Pereira, Dong Lin, Linda Pelleymounter, Irene Moon, Gail Stilling, Bruce W. Eckloff, Eric D. Wieben, Margaret M. Redfield, John C. Burnett, Jr, Vivien C. Yee, and Richard M. Weinshilboum, Circ Cardiovasc Genet, Apr 2013; 6: 201 - 210. [NPR3]

A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene, Hui Wei, Tapan K. Bera, Alan S. Wayne, Laiman Xiang, Simona Colantonio, Oleg Chertov, and Ira Pastan, J. Biol. Chem., Apr 2013; 288: 12305 - 12312. [WDR85]

Arachidonic Acid–Induced Dilation in Human Coronary Arterioles: Convergence of Signaling Mechanisms on Endothelial TRPV4-Mediated Ca2+ Entry, Xiaodong Zheng, Natalya S. Zinkevich, Debebe Gebremedhin, Kathryn M. Gauthier, Yoshinori Nishijima, Juan Fang, David A. Wilcox, William B. Campbell, David D. Gutterman, and David X. Zhang, JAHA, Apr 2013; 2: e000080. [TRPV4 ]

Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines, Urszula Oleksiewicz, Triantafillos Liloglou, Kalliopi-Maria Tasopoulou, Nikoleta Daskoulidou, Julie Bryan, John R. Gosney, John K. Field, and George Xinarianos, Hum. Mol. Genet., Apr 2013; 10.1093/hmg/ddt174. [CYGB ]

Comparative Phosphoproteomic Analysis of Checkpoint Recovery Identifies New Regulators of the DNA Damage Response, Vincentius A. Halim, Mónica Alvarez-Fernández, Yan Juan Xu, Melinda Aprelia, Henk W. P. van den Toorn, Albert J. R. Heck, Shabaz Mohammed, and René H. Medema, Sci. Signal., Apr 2013; 6: rs9. [SPAG5]

More TrueClone Citations >>

NAT1 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC209011	Mus musculus N-acetyl transferase 1 (Nat1) as transfection-ready DNA	10 ug	$380	3 weeks
MR220038	Myc-DDK-tagged ORF clone of Mus musculus N-acetyl transferase 1 (Nat1) as transfection-ready DNA	10 ug	$380	3 weeks
MG220038	GFP-tagged ORF clone of Mus musculus N-acetyl transferase 1 (Nat1) as transfection-ready DNA	10 ug	$420	3 weeks

NAT1 Rat Clones

SKU	Description	Amount	Price	Shipping
RN200227	NativeORF clone of Rattus norvegicus N-acetyltransferase 1 (arylamine N-acetyltransferase) (Nat1), transcript variant 2 as transfection-ready DNA	10 ug	$380	3 weeks
RR200227	Myc-DDK-tagged ORF clone of Rattus norvegicus N-acetyltransferase 1 (arylamine N-acetyltransferase) (Nat1), transcript variant 2 as transfection-ready DNA	10 ug	$380	3 weeks

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NAT1 (NM_001160173) Human cDNA Clone

TrueClone Citations:

NAT1 Mouse Clones

NAT1 Rat Clones

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