PMP70 (ABCD3) (NM_002858) Human Untagged Clone

CAT#: SC118377

ABCD3 (untagged)-Human ATP-binding cassette, sub-family D (ALD), member 3 (ABCD3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PMP70
• Synonyms: ABC43; CBAS5; PMP70; PXMP1; ZWS2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC118377 sequence for NM_002858 edited (data generated by NextGen Sequencing)
  ATGGCGGCCTTCAGCAAGTACTTGACGGCGCGAAACTCCTCGCTGGCTGGTGCCGCGTTC
  CTGCTGCTCTGCCTGCTCCACAAGCGGCGCCGCGCCCTCGGCCTGCACGGTAAGAAAAGT
  GGAAAACCACCATTACAGAACAATGAGAAAGAGGGGAAAAAGGAGCGAGCTGTGGTGGAC
  AAGGTGTTTTTCTCAAGGCTCATACAGATTCTGAAAATCATGGTCCCTAGAACATTTTGT
  AAAGAGACAGGTTACTTGGTACTTATTGCTGTTATGCTGGTGTCTCGAACATATTGTGAT
  GTTTGGATGATTCAAAATGGGACACTAATTGAAAGTGGTATCATTGGTCGTAGCAGGAAA
  GATTTCAAGAGATACTTACTCAACTTCATCGCTGCCATGCCTCTTATCTCTCTGGTTAAT
  AACTTCTTGAAGTATGGGTTAAATGAGCTTAAACTGTGCTTCCGAGTAAGGCTCACTAAA
  TACCTCTATGAGGAGTATCTTCAAGCTTTCACATATTATAAAATGGGGAATCTGGACAAC
  AGAATAGCTAATCCAGACCAGCTGCTTACACAAGATGTAGAAAAATTTTGTAACAGTGTA
  GTCGATCTGTATTCAAATCTTAGTAAGCCATTTTTAGACATAGTTTTGTATATCTTTAAG
  TTAACGAGTGCAATTGGAGCTCAGGGCCCAGCGAGCATGATGGCCTACTTGGTTGTTTCT
  GGGCTATTCCTAACTCGACTTCGAAGACCCATTGGTAAGATGACAATAACTGAGCAAAAG
  TATGAAGGAGAATATAGATATGTTAATTCTCGGCTCATCACAAACAGTGAAGAAATTGCC
  TTTTACAATGGGAATAAAAGAGAAAAGCAGACAGTCCACTCAGTCTTCCGAAAACTGGTG
  GAACACCTACATAATTTCATTTTGTTTCGGTTTTCAATGGGCTTCATTGATAGTATTATT
  GCCAAATACCTTGCCACTGTTGTTGGTTACCTAGTTGTCAGTCGCCCTTTCTTAGATTTG
  TCTCATCCTCGACATCTCAAGAGTACACATTCGGAACTTCTAGAGGATTACTACCAAAGT
  GGAAGAATGCTTTTGCGAATGTCTCAAGCTCTGGGTCGAATAGTTTTGGCTGGGCGTGAA
  ATGACTAGATTGGCCGGTTTTACTGCTCGGATTACAGAATTAATGCAAGTACTGAAGGAT
  TTAAATCATGGCAAATATGAGCGCACAATGGTCTTACAACAGGAAAAGGGTATTGAAGGA
  GTACAAGTCATTCCCTTGATACCTGGTGCTGGAGAAATCATTATTGCAGATAACATTATA
  AAGTTTGATCATGTTCCTTTAGCAACGCCAAATGGAGATGTTTTGATCCGAGACCTTAAT
  TTTGAAGTTCGATCTGGGGCTAATGTTCTAATTTGTGGTCCAAATGGCTGCGGAAAGAGT
  TCACTTTTCCGTGTTCTTGGTGAATTATGGCCTCTTTTTGGAGGACGTCTAACTAAACCT
  GAAAGAGGAAAATTATTTTATGTTCCTCAGAGACCTTACATGACCCTTGGAACACTTCGA
  GATCAAGTGATATATCCAGATGGACGAGAAGATCAGAAAAGGAAGGGAATTTCTGACCTA
  GTACTGAAGGAATACTTAGACAATGTCCAGTTGGGTCATATCCTTGAACGTGAAGGAGGC
  TGGGACAGTGTTCAGGATTGGATGGACGTACTCAGTGGTGGAGAAAAGCAAAGAATGGCG
  ATGGCAAGATTATTTTATCATAAACCCCAGTTTGCCATTTTGGATGAATGCACAAGTGCA
  GTTAGTGTCGACGTGGAAGGCTACATTTATAGTCATTGTCGAAAGGTTGGCATCACTCTC
  TTCACTGTGTCTCATAGGAAATCTCTTTGGAAACATCATGAGTACTACCTGCATATGGAT
  GGCAGAGGCAACTATGAATTCAAACAGATAACAGAAGATACAGTTGAGTTTGGCTCTTAG
  
  Clone variation with respect to NM_002858.3
  1235 c=>t
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002858 unedited
  ACACCAATTCCGCACGAGGCCTCGTGCCTAATTCGGCACGAGGGCTGCGTGCAGTAAGGT
  AGCCGCCGCCGCCGCCGCCGCCGCGTCCCCTCGCCGGCTCGCTGGTACCGGCAGTGCCAT
  GGCGGCCTTCAGCAAGTACTTGACGGCGCGAAACTCCTCGCTGGCTGGTGCCGCGTTCNG
  TTGCTTTGCCTGCTCCACAAGCGGCGCCGCGCCCTCGGCCTGCACGGTAAGAAAAGTGGA
  AAACCACCATTACAGAACAATGAGAAAGAGGGGAAAAAGGAGCGAGCTGTGGTGGACAAG
  GTGTTTTTCTCAAGGCTCATACAGATTCTGAAAATCATGGTCCCTAGAACATTTTGTAAA
  GAGACAGGTTACTTGGTACTTATTGCTGTTATGCTGGTGTCTCGAACATATTGTGATGTT
  TGGATGATTCAAAATGGGACACTAATTGAAAGTGGTATCATTGGTCGTAGCAGGAAAGAT
  TTCAAGAGATACTTACTCAACTTCATCGCTGCCATGCCTCTTATCTCTCTGGTTAATAAC
  TTCTTGAAGTATGGGTTAAATGAGCTTAAACTGTGCTTCCGAGTAAGGCTCACTAAATAC
  CTCTATGAGGAGTATCTTCAAGCTTTCACATATTATAAAATGGGGAATCTGGACAACAGA
  ATAGCTAATCCAGACCAGCTGCTTACACAAGATGTAGAAAAATTTTGTAACAGTGTAGTC
  GATCTGTATTCAAATCTTATAAGCCATTTTTTAGACTAGTTTTGTATATCTTTAAGTTAA
  CGAGTGCAATTGGAGCTCAGGGCCCCAGCGAGCATGATGGCCTACCTGGNTGTTTTCTGG
  GCTATTCTTAACTCCACTTCAAGAACCAATGGTTAGATGACATTACTGAGCAN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002858 unedited
  CGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGATCTGAACAGAAAAAAGTATACAA
  GTTCGCTAAACAGAAGTGGTAAAAATTGAATGTTATGTATTATGGAATTCAGTACATCAG
  TTTACTTCGGTAGCCAGTGATTGTTATAGTTAATTCTGCAAAAAAACAAAACCAGTTATG
  CAAAAACAAGAGTACAAAATGCCCCTTTCTGAAGCTCAGTTTGAGAAACTGATTTCGTAT
  CTAGCTTATTGATTATACTCAGTTTCAATTCTCCCTGTGCAAATAATACATAAAGTCATT
  AATGATGATTTGATGAACTGAAATCATCTTCGCTTAGGATCGTTTGACATCATAACCCAA
  ATATAAAAAAGTTATTCAAGATTCACAGAGATAAAACAGTGCCTCGGAAACATAATTCAC
  CCATGTATATATAATAATTTTAGAACATACTTTTTAAACATAAAATCACAGTCAAAGACA
  GTGATAGCATTGCATACTCAGTGCATTATTTCATGTAGTGCCTTCCTATGGCTCATTTGG
  AGTTTAATACCAAATAACCACCACACTTCTAATGAATGGGCTTCTAACACACACAAATTT
  GTCTAATTCTCTTAAAAATCTAGAACTCTTATAAGACCTTGAGCCTGGCATGTTAAGGAC
  TTTGTGTTTTAATATCCCAAACATTGGGAAGATTANGTGTGATACATGGTAACCCCCTNC
  TTTGTAGCAAGACTGCACATATACTTTAAACAACTCAATACTGCAGACTGAGAAGGGTAC
  ATTTATCATTTAGTTAAGGAAAACCAAATGGCCTTTCCTGGAGGTAATGCACTCCCAGAC
  CACACAAGGATGAGTATACTGGGCAGCTAAGAAATTGCCCTGATAATAACCTGTATGCAT
  GATGTAACATTTATAATCATATGATCGTTCCACTACCAGGCACAGAAAATGACTGAGACT
  TCTGCTAACGGCAATGAGACCAGTTTATAAGGTCTACTGAG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002858
• Insert Size: 3160 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002858.2, NP_002849.1
• RefSeq Size: 3423 bp
• RefSeq ORF: 1980 bp
• Locus ID: 5825
• UniProt ID: P28288
• Cytogenetics: 1p21.3
• Domains: ABC_tran, AAA
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ABC transporters
• Gene Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).