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 Home TrueClone RFXANK Clone

RFXANK (NM_134440) Human cDNA Clone

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC109969 Homo sapiens regulatory factor X-associated ankyrin-containing protein (RFXANK), transcript variant 2 as transfection-ready DNA NM_134440.1, 10ug $380 4 weeks
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA504261 Purified RFXANK mouse monoclonal antibody,clone 3C10, 100ul $379 In Stock
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OriGene Data
Vector:pCMV6-XL6 Insert Size: 1400 Restriction Site: NotI-NotI
Sequence Data: 5' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Transcription FactorsDruggable Genome
Protein Pathways: Antigen processing and presentationPrimary immunodeficiency
Reference Data
RefSeq: NM_134440.1, NP_604389
 RefSeq Size: 1369 RefSeq ORF: 714
Synonyms : ANKRA1; BLS; F14150_1; RFX-B
LocusID: 8625 Cytogenetic: 19p12
Summary: Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity. [provided by RefSeq, Jul 2008].

Transcript Variant: This variant (2) lacks 3 nt at the 5' end of a coding exon, and a 66 nt coding exon, as compared to transcript variant 1. As a result, variant 2 encodes isoform b, which lacks an internal single aa and an internal 22 aa stretch as compared to isoform a encoded by variant 1. Isoform b lacks the activation activity of isoform a.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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