Integrin alpha 1 (ITGA1) (NM_181501) Human Untagged Clone

CAT#: SC107298

ITGA1 (untagged)-Human integrin, alpha 1 (ITGA1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Integrin alpha 1
• Synonyms: CD49a; VLA1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC107298 sequence for NM_181501 edited (data generated by NextGen Sequencing)
  ATGGCCCCTCGGCCCCGCGCCCGCCCAGGGGTCGCTGTCGCCTGCTGCTGGCTCCTCACT
  GTTGTTCTACGCTGCTGCGTATCATTCAATGTTGATGTGAAAAATTCAATGACTTTCAGC
  GGCCCGGTGGAAGACATGTTTGGATATACTGTTCAACAATATGAAAATGAAGAAGGAAAA
  TGGGTGCTTATTGGTTCTCCGTTAGTTGGCCAACCCAAAAACAGAACTGGAGATGTCTAT
  AAGTGTCCAGTTGGGAGAGGTGAATCATTACCTTGTGTAAAGTTGGATCTACCAGTTAAT
  ACATCAATTCCCAATGTCACAGAAGTAAAGGAGAACATGACATTTGGATCAACTTTAGTC
  ACCAACCCAAATGGAGGATTTCTGGCTTGTGGGCCCTTATATGCCTATAGATGTGGACAT
  TTGCATTACACAACTGGAATCTGTTCTGACGTCAGCCCCACATTTCAAGTCGTGAATTCC
  ATTGCCCCTGTACAAGAATGCAGCACTCAACTGGACATAGTCATAGTGCTGGATGGTTCC
  AACAGTATTTACCCATGGGACAGTGTTACAGCTTTTTTAAATGACCTTCTTGAAAGAATG
  GATATTGGTCCTAAACAGACACAGGTTGGAATTGTACAGTATGGAGAAAACGTGACCCAT
  GAGTTCAACCTCAATAAGTATTCTTCCACCGAAGAGGTACTTGTTGCAGCAAAGAAAATA
  GTCCAGAGAGGTGGCCGCCAGACTATGACAGCTCTTGGAATAGACACAGCAAGAAAGGAG
  GCATTCACGGAAGCCCGGGGTGCCCGAAGAGGAGTTAAAAAAGTCATGGTTATTGTGACA
  GATGGAGAGTCTCATGACAATCATCGACTGAAGAAGGTCATCCAAGACTGTGAAGATGAA
  AACATTCAACGGTTTTCCATAGCTATTCTTGGCAGCTATAACCGAGGAAATTTAAGCACT
  GAAAAATTTGTGGAGGAAATAAAATCAATTGCAAGTGAACCCACTGAAAAGCATTTCTTC
  AATGTCTCTGATGAATTGGCTCTAGTCACCATTGTTAAAACTCTGGGAGAAAGAATATTT
  GCCCTGGAAGCCACAGCTGACCAGTCAGCAGCTTCATTTGAAATGGAAATGTCTCAGACT
  GGCTTCAGTGCTCATTATTCACAGGACTGGGTCATGCTTGGAGCAGTAGGAGCCTATGAT
  TGGAATGGAACAGTTGTCATGCAGAAGGCTAGTCAAATCATAATCCCTCGAAACACAACC
  TTTAATGTTGAGTCTACCAAAAAGAATGAACCGCTTGCTTCTTATTTAGGTTACACTGTA
  AACTCTGCTACTGCTTCTTCTGGAGATGTGCTCTATATTGCTGGACAGCCTCGGTACAAT
  CATACAGGCCAGGTCATTATCTACAGGATGGAAGATGGAAACATCAAAATTCTCCAGACG
  CTCAGTGGAGAACAGATTGGTTCCTACTTTGGCAGTATTTTAACAACAACTGACATTGAC
  AAGGATTCTAATACTGACATTCTTCTAGTCGGAGCCCCTATGTACATGGGAACAGAGAAG
  GAGGAGCAAGGAAAAGTGTATGTGTATGCTCTCAATCAGACAAGGTTTGAATATCAAATG
  AGCCTGGAACCTATTAAGCAGACGTGCTGTTCATCTCGGCAGCACAATTCATGCACAACA
  GAAAACAAAAATGAGCCATGCGGGGCTCGTTTTGGAACTGCAATTGCTGCTGTAAAAGAC
  CTCAATCTTGATGGATTTAATGACATCGTGATAGGAGCTCCGCTGGAAGATGATCACGGG
  GGAGCTGTGTACATTTATCATGGAAGTGGCAAGACTATAAGGAAAGAGTATGCACAACGT
  ATTCCATCAGGTGGGGATGGTAAGACACTGAAATTTTTTGGCCAGTCTATCCACGGAGAA
  ATGGATTTAAATGGTGACGGTCTGACAGATGTGACTATTGGGGGCCTTGGTGGTGCTGCC
  CTCTTCTGGTCCCGAGATGTGGCCGTAGTTAAAGTGACCATGAATTTTGAGCCAAATAAA
  GTGAATATTCAAAAGAAAAACTGCCATATGGAGGGAAAGGAAACAGTATGCATAAATGCT
  ACAGTGTGTTTTGATGTGAAATTAAAGTCTAAAGAAGACACGATTTATGAAGCTGATTTG
  CAGTACCGTGTCACCCTAGATTCACTAAGACAAATATCACGAAGTTTTTTCTCTGGAACT
  CAAGAGAGAAAGGTTCAAAGGAACATCACAGTTCGAAAATCAGAATGCACTAAGCACTCC
  TTCTACATGTTGGACAAGCATGACTTTCAGGACTCTGTGAGAATAACGTTGGACTTTAAT
  CTTACCGATCCAGAAAATGGGCCTGTTCTTGATGATTCTCTACCAAACTCAGTACATGAA
  TATATTCCCTTTGCCAAAGATTGTGGAAATAAGGAAAAATGTATCTCAGACCTCAGCCTG
  CATGTCGCCACCACTGAAAAGGACCTGCTGATTGTCCGATCCCAGAATGATAAGTTCAAC
  GTTAGCCTCACAGTCAAAAATACAAAGGACAGTGCCTATAACACCAGGACAATAGTGCAT
  TATTCTCCAAATCTAGTTTTTTCAGGAATTGAGGCTATCCAAAAAGACAGTTGTGAATCT
  AATCATAATATCACATGTAAAGTTGGATATCCCTTCCTGAGAAGAGGAGAGATGGTAACT
  TTCAAAATATTGTTTCAGTTTAACACATCCTATCTCATGGAAAATGTGACCATTTATTTA
  AGTGCAACAAGTGACAGCGAAGAACCTCCTGAAACCCTTTCTGATAATGTAGTAAACATT
  TCTATCCCGGTAAAATATGAAGTTGGACTACAGTTTTACAGCTCTGCAAGTGAATACCAC
  ATTTCAATTGCTGCCAATGAGACAGTCCCTGAAGTTATTAATTCTACTGAGGACATTGGA
  AATGAAATTAATATCTTCTACTTGATTAGAAAAAGTGGATCTTTTCCAATGCCAGAGCTT
  AAGCTGTCAATTTCATTCCCCAATATGACATCAAATGGTTACCCTGTGCTGTACCCAACT
  GGATTGTCATCTTCTGAGAATGCAAACTGCAGACCCCATATCTTTGAGGATCCTTTCAGT
  ATCAACTCTGGAAAGAAAATGACTACATCAACTGACCATCTCAAACGAGGCACAATTCTG
  GACTGCAATACATGTAAATTTGCTACCATCACATGTAATCTCACTTCTTCTGACATCAGC
  CAAGTCAATGTTTCGCTTATCTTGTGGAAACCAACTTTTATAAAATCATATTTTTCCAGC
  TTAAATCTTACTATAAGGGGAGAACTTCGGAGTGAAAATGCATCTCTGGTTTTAAGTAGC
  AGCAATCAAAAAAGAGAGCTTGCTATTCAAATATCCAAAGATGGGCTACCGGGCAGAGTG
  CCATTATGGGTCATCCTGCTGAGTGCTTTTGCCGGATTGTTGCTGTTAATGCTGCTCATT
  TTAGCACTGTGGAAGATTGGATTCTTCAAAAGACCACTGAARAAGAAAATGGAGAAATGA
  
  Clone variation with respect to NM_181501.1
  3522 a=>r
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_181501 unedited
  GGGCGCTCGTAGGNAATTATGANAACACGNATTTCACTATAGNNGGCGGCCGCGNAATTC
  GGCACGAGGGCAGCGGGATAAGTGGCCCAGCCAGAGAGCGCAGCTCCCGCGCCCGGTCCT
  GCCCTGCGAACCAGCGCGGCCCCCTGGCGCTGAGGCTGCTCCGGCCATGGCCCCTCGGCC
  CCGCGCCCGCCCAGGGGTCGCTGTCGCCTGCTGCTGGCTCCTCACTGTTGTTCTACGCTG
  CTGCGTATCATTCAATGTTGATGTGAAAAATTCAATGACTTTCAGCGGCCCGGTGGAAGA
  CATGTTTGGATATACTGTTCAACAATATGAAAATGAAGAAGGAAAATGGGTGCTTATTGG
  TTCTCCGTTAGTTGGCCAACCCAAAAACAGAACTGGAGATGTCTATAAGTGTCCAGTTGG
  GAGAGGTGAATCATTACCTTGTGTAAAGTTGGATCTACCAGTTAATACATCAATTCCCAA
  TGTCACAGAAGTAAAGGAGAACATGACATTTGGATCAACTTTAGTCACCAACCCAAATGG
  AGGATTTCTGGCTTGTGGGCCCTTATATGCCTATAGATGTGGACATTTGCATTACACAAC
  TGGAATCTGTTCTGACGTCAGCCCCACATTTCAAGTCGTGAATTCCATTGCCCCTGTACA
  AGAATGCAGCACTCAACTGGACATAGTCATAGTGCTGGATGGTTCCAACAGTATTTACCC
  ATGGGACAGTGTTACAGCTTNTTTAAATGACCTTCTTGAAAGATGGATATTGGTCCTAAA
  CAGACACAGGTTGGAATTGTACAGTATGGAGAAAACGTGACCCATGAGTNCAACCTCAAT
  AAGTATCCTTCCACCGAAGAGTACTCGTTGCAGCAAAGAAATAGTCCAGAGAGTGGCCGC
  CAGATATGACAGCTCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_181501 unedited
  CATTGGNNGATGGCACTTNCCAGGNCCAGNANGAGCCTGGGNGAGGGTCACAGGGATGCC
  ACCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTT
  TTTTTTTTTTTTAGATTATTGAATAATTGTTATTATTTTCTTTCATAAAATATTTCATTT
  CTCCATTTTCTTCTTCAGTGGTCTTTTGAAGAATCCAATCTTCCACAGTGCTAAAATGAG
  CAGCATTAACAGCAACAATCCGGCAAAAGCACTCAGCAGGATGACCCATAATGGCACTCT
  GCCCGGTAGCCCATCTTTGGATATTTGAATAGCAAGCTCTCTTTTTTGATTGCTGCTACT
  TAAAACCAGAGATGCATTTTCACTCCGAAGTTCTCCCCTTATAGTAAGATTTAAGCTGGA
  AAAATATGATTTTATAAAAGTTGGTTTCCACAAGATAAGCGAAACATTGACTTGGCTGAT
  GTCAGAAGAAGTGAGATTACATGTGATGGTAGCAAATTTACATGTATTGCAGTCCAGAAT
  TGTGCCTCGTTTGAGATGGTCAGTTGATGTAGTCATTTTCTTTCCAGAGTTGATACTGAA
  AGGATCCTCANAGATATGGGGTCTGCAGTTTGCATTCTCAGAAGATGACAATCCAGTTGG
  GTACAGCACAGGGTAACCATTTGATGTCATATTGGGGAATGAAATTGACAGCTTAAGCTC
  TGGCATTGGAAAAGATCCACTTTTTCTATCAAGTAGAAGATATAATTTCATTTCCAATGT
  CCTCCATAGATTAATAACTTCAGGACTGTCTCATTGGCAGCCATTGAAATGTGGTATTCA
  CTTGCAGAGCTGGTAAACTGTAGTTCAACTTCATATTTTACCGGAATAAAAATGTTACTA
  CCTTATCAGAAAGGTTTTCAGGAGTN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_181501
• Insert Size: 3900 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_181501.1, NP_852478.1
• RefSeq Size: 4811 bp
• RefSeq ORF: 3540 bp
• Locus ID: 3672
• UniProt ID: P56199
• Cytogenetics: 5q11.2
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton
• Gene Summary: This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]