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 Home cDNA Clone TrueORF All GRM1 ORF Clones

GRM1 (NM_001114329) Human cDNA ORF Clone

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Cat. No. Description Price Availability  
RG226254 GFP-tagged ORF clone of Homo sapiens glutamate receptor, metabotropic 1 (GRM1), transcript variant 2 as transfection-ready DNA, 10µg
$1430
 5-6 weeks

$50 off anti-DDK and other anti-tag antibodies till June 30th, 2013

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Also for GRM1 (NM_001114329)
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TrueORF Data for RG226254
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Vector: pCMV6-AC-GFP   Change vector? Tag: C-terminal TurboGFP
Sequence Data: ORF Nucleotide Sequence
Protein Sequence 		ORF Size: 2721 bp
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map Plasmid Map
OTI Annotation: This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: GPCRTransmembraneDruggable Genome
Protein Pathways: Calcium signaling pathwayNeuroactive ligand-receptor interactionGap junctionLong-term potentiationLong-term depression
* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data
RefSeq: NM_001114329.1, NP_001107801
 RefSeq Size: RefSeq ORF: 2721
Synonyms : GPRC1A; GRM1A; mGlu1; MGLUR1; MGLUR1A; SCAR13
LocusID: 2911 Cytogenetic: 6q24
Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq, Jul 2008].

 
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