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Home cDNA Clone TrueORF All SOCS1 ORF Clones

SOCS1 (NM_003745) Human cDNA ORF Clone

Specifications Citations Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RG220847 SOCS1 (GFP-tagged) - Human suppressor of cytokine signaling 1 (SOCS1), 10µg
$420
In Stock
TA150041 2H8, Anti-tGFP monoclonal antibody, 100µl $248 In Stock
Clone Modification
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Also for SOCS1 (NM_003745)
cDNA Clone shRNA/siRNA Lysate Protein Antibody
TrueORF Data for RG220847
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Vector: pCMV6-AC-GFP   Change vector? Tag: C-terminal TurboGFP
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 636 bp
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map Plasmid Map
OTI Annotation: This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Stem cell relevant signaling - JAK/STAT signaling pathwayStem cell - PluripotencyDruggable Genome
Protein Pathways: Ubiquitin mediated proteolysisJak-STAT signaling pathwayInsulin signaling pathwayType II diabetes mellitus

Reference Data
RefSeq: NM_003745.1, NP_003736
RefSeq Size: 1216 RefSeq ORF: 636
Synonyms : CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3
LocusID: 8651 Cytogenetic: 16p13.13 Domains: SH2, SOCS
Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul

 

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