OriGene - CCNE2 (NM_057749) Human ORF cDNA Clone

Western Blot Validated

TrueORF Data for RG218597

Vector:	pCMV6-AC-GFP Change vector?	Tag: C-terminal TurboGFP	Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Sequence Data:	ORF Nucleotide Sequence CHROMATOGRAMS Protein Sequence	ORF Size: 1215 bp Predicted Protein MW: 46.6 kDa
Restriction Sites:	SgfI-MluI Cloning Scheme for this gene Plasmid Map
OTI Annotation:	This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer:	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components:	The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families:	Druggable Genome
Protein Pathways:	Cell cycle Oocyte meiosis p53 signaling pathway Pathways in cancer Prostate cancer Small cell lung cancer

* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data

RefSeq: NM_057749.1, NP_477097	RefSeq Size: 2748	RefSeq ORF: 1215
Synonyms : CYCE2
LocusID: 9134	Cytogenetic: 8q22.1	Domains: cyclin_C, CYCLIN, cyclin
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008].

ORF Clones Citations:

Solute Carrier 11A1 Is Expressed by Innate Lymphocytes and Augments Their Activation, Jodi F. Hedges, Emily Kimmel, Deann T. Snyder, Maria Jerome, and Mark A. Jutila, J. Immunol., Apr 2013; 190: 4263 - 4273. [SLC11A1]

A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function, Feng Gao, Hansel E. Ihn, Marisa W. Medina, and Ronald M. Krauss, Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [LDLR]

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP, Lisa Muniz, Sylvain Egloff, and Tamás Kiss, Nucleic Acids Res., Apr 2013; 41: 4686 - 4698. [MEPCE ]

Structural basis for angiopoietin-1–mediated signaling initiation, Xuehong Yu, Tom C. M. Seegar, Annamarie C. Dalton, Dorothea Tzvetkova-Robev, Yehuda Goldgur, Kanagalaghatta R. Rajashankar, Dimitar B. Nikolov, and William A. Barton, PNAS, Apr 2013; 110: 7205 - 7210. [ANGPT1]

Inverted Formin 2 Regulates Actin Dynamics by Antagonizing Rho/Diaphanous-related Formin Signaling, Hua Sun, Johannes Schlondorff, Henry N. Higgs, and Martin R. Pollak, J. Am. Soc. Nephrol., Apr 2013; 10.1681/ASN.2012080834. [INF2]

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway, Chutima Kumkhaek, Wulin Aerbajinai, Wenli Liu, Jianqiong Zhu, Naoya Uchida, Roger Kurlander, Matthew M. Hsieh, John F. Tisdale, and Griffin P. Rodgers, Blood, Apr 2013; 121: 3216 - 3227. [MFHAS1 ]

Proximal tubule-dominant transfer of AT1a receptors induces blood pressure responses to intracellular angiotensin II in AT1a receptor-deficient mice, Xiao C. Li and Jia L. Zhuo, Am J Physiol Regulatory Integrative Comp Physiol, Apr 2013; 304: R588 - R598. [AGTR1A ]

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase, Pardeep Heir, Roxana I. Sufan, Samantha N. Greer, Betty P. Poon, Jeffrey E. Lee, and Michael Ohh, Mol. Cell. Biol., Apr 2013; 33: 1621 - 1631. [DCNL1]

More TrueClone Citations >>

CCNE2 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC202066	Mus musculus cyclin E2 (Ccne2), transcript variant 1 as transfection-ready DNA	10 ug	$165	Next day
MR206360	Myc-DDK-tagged ORF clone of Mus musculus cyclin E2 (Ccne2), transcript variant 1 as transfection-ready DNA	10 ug	$380	4 weeks
MR223497	Myc-DDK-tagged ORF clone of Mus musculus cyclin E2 (Ccne2), transcript variant 2 as transfection-ready DNA	10 ug	$380	4 weeks
MG206360	GFP-tagged ORF clone of Mus musculus cyclin E2 (Ccne2), transcript variant 1 in a GFP expression vector	10 ug	$420	3 weeks
MG223497	GFP-tagged ORF clone of Mus musculus cyclin E2 (Ccne2) transcript variant 2 as transfection-ready DNA	10 ug	$420	3 weeks

CCNE2 Rat Clones

SKU	Description	Amount	Price	Shipping
RN213657	NativeORF clone of Rattus norvegicus cyclin E2 (Ccne2) as transfection-ready DNA	10 ug	$380	4 weeks
RR213657	Myc-DDK-tagged ORF clone of Rattus norvegicus cyclin E2 (Ccne2) as transfection-ready DNA	10 ug	$380	4 weeks

Don't see the species of your interest?
Use Blue Heron gene synthesis and make clone in any of OriGene's expression vectors.

All Products by:	Title \| Price \| Category \| Popularity \| Best Sellers	Topselling Products by:	Title \| Price \| Category \| Popularity \| Favorites
Popular Categories:	Popularity \| Our Choices \| All-Round Favorites \| Title	Topselling Categories:	Popularity \| Our Choices \| All-Round Favorites \| Title

CCNE2 (NM_057749) Human cDNA ORF Clone

Western Blot Validated

ORF Clones Citations:

CCNE2 Mouse Clones

CCNE2 Rat Clones

Product Manuals

MSDS

FAQs