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Home cDNA Clone TrueORF All IGF1R ORF Clones

IGF1R (NM_000875) Human cDNA ORF Clone

Specifications Citations Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RG214928 IGF1R (GFP-tagged) - Human insulin-like growth factor 1 receptor (IGF1R), 10µg
$860
In Stock
TA150041 2H8, Anti-tGFP monoclonal antibody, 100µl $248 In Stock
Clone Modification
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Also for IGF1R (NM_000875)
cDNA Clone shRNA/siRNA Lysate Protein Antibody
TrueORF Data for RG214928
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Vector: pCMV6-AC-GFP   Change vector? Tag: C-terminal TurboGFP
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 4104 bp
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map Plasmid Map
OTI Annotation: This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Protein KinaseTransmembraneDruggable Genome
Protein Pathways: Oocyte meiosisEndocytosisFocal adhesionAdherens junctionLong-term depressionProgesterone-mediated oocyte maturationMore Pathways >>

Reference Data
RefSeq: NM_000875.2, NP_000866
RefSeq Size: 4989 RefSeq ORF: 4104
Synonyms : CD221; IGFIR; IGFR; JTK13
LocusID: 3480 Cytogenetic: 15q26.3
Summary: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May

 

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