OriGene - RBPJ (NM_203284) Human ORF cDNA Clone

Western Blot Validated

TrueORF Data for RG209094

Vector:	pCMV6-AC-GFP Change vector?	Tag: C-terminal TurboGFP	Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Sequence Data:	ORF Nucleotide Sequence CHROMATOGRAMS Protein Sequence	ORF Size: 1461 bp Predicted Protein MW: 54.2 kDa
Restriction Sites:	SgfI-MluI Cloning Scheme for this gene Plasmid Map
OTI Annotation:	This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer:	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components:	The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families:	Transcription Factors
Protein Pathways:	Notch signaling pathway

* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data

RefSeq: NM_203284.1, NP_976029	RefSeq Size: 2499	RefSeq ORF: 1461
Synonyms : AOS3; CBF1; csl; IGKJRB; IGKJRB1; KBF2; RBP-J; RBPJK; RBPSUH; SUH
LocusID: 3516	Cytogenetic: 4p15.2
Summary: The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Also, this protein can bind specifically to the recombination signal sequence of immunglobulin kappa type J segments. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2011].

ORF Clones Citations:

Solute Carrier 11A1 Is Expressed by Innate Lymphocytes and Augments Their Activation, Jodi F. Hedges, Emily Kimmel, Deann T. Snyder, Maria Jerome, and Mark A. Jutila, J. Immunol., Apr 2013; 190: 4263 - 4273. [SLC11A1]

A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function, Feng Gao, Hansel E. Ihn, Marisa W. Medina, and Ronald M. Krauss, Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [LDLR]

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP, Lisa Muniz, Sylvain Egloff, and Tamás Kiss, Nucleic Acids Res., Apr 2013; 41: 4686 - 4698. [MEPCE ]

Structural basis for angiopoietin-1–mediated signaling initiation, Xuehong Yu, Tom C. M. Seegar, Annamarie C. Dalton, Dorothea Tzvetkova-Robev, Yehuda Goldgur, Kanagalaghatta R. Rajashankar, Dimitar B. Nikolov, and William A. Barton, PNAS, Apr 2013; 110: 7205 - 7210. [ANGPT1]

Inverted Formin 2 Regulates Actin Dynamics by Antagonizing Rho/Diaphanous-related Formin Signaling, Hua Sun, Johannes Schlondorff, Henry N. Higgs, and Martin R. Pollak, J. Am. Soc. Nephrol., Apr 2013; 10.1681/ASN.2012080834. [INF2]

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway, Chutima Kumkhaek, Wulin Aerbajinai, Wenli Liu, Jianqiong Zhu, Naoya Uchida, Roger Kurlander, Matthew M. Hsieh, John F. Tisdale, and Griffin P. Rodgers, Blood, Apr 2013; 121: 3216 - 3227. [MFHAS1 ]

Proximal tubule-dominant transfer of AT1a receptors induces blood pressure responses to intracellular angiotensin II in AT1a receptor-deficient mice, Xiao C. Li and Jia L. Zhuo, Am J Physiol Regulatory Integrative Comp Physiol, Apr 2013; 304: R588 - R598. [AGTR1A ]

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase, Pardeep Heir, Roxana I. Sufan, Samantha N. Greer, Betty P. Poon, Jeffrey E. Lee, and Michael Ohh, Mol. Cell. Biol., Apr 2013; 33: 1621 - 1631. [DCNL1]

More TrueClone Citations >>

RBPJ Mouse Clones

SKU	Description	Amount	Price	Shipping
MC206648	Mus musculus recombination signal binding protein for immunoglobulin kappa J region (cDNA clone MGC:54902 as transfection-ready DNA	10 ug	$165	Next day
MR207810	Myc-DDK-tagged ORF clone of Mus musculus recombination signal binding protein for immunoglobulin kappa J region (Rbpj), transcript variant 2 as transfection-ready DNA	10 ug	$590	Next day
MR226108	Myc-DDK-tagged ORF clone of Mus musculus recombination signal binding protein for immunoglobulin kappa J region (Rbpj), transcript variant 1 as transfection-ready DNA	10 ug	$630	4 weeks
MR226116	Myc-DDK-tagged ORF clone of Mus musculus recombination signal binding protein for immunoglobulin kappa J region (Rbpj), transcript variant 3 as transfection-ready DNA	10 ug	$580	4 weeks
MG207810	GFP-tagged ORF clone of Mus musculus recombination signal binding protein for immunoglobulin kappa J region (Rbpj), transcript variant 2 in a GFP expression vector	10 ug	$650	3 weeks
MG226108	GFP-tagged ORF clone of Mus musculus recombination signal binding protein for immunoglobulin kappa J region (Rbpj) transcript variant 1 as transfection-ready DNA	10 ug	$690	3 weeks
MG226116	GFP-tagged ORF clone of Mus musculus recombination signal binding protein for immunoglobulin kappa J region (Rbpj) transcript variant 3 as transfection-ready DNA	10 ug	$640	3 weeks

RBPJ Rat Clones

SKU	Description	Amount	Price	Shipping
RN215087	NativeORF clone of Rattus norvegicus similar to Recombining binding protein suppressor of hairless (J kappa-recombination signal binding protein) (RBP-J kappa) (LOC679028) as transfection-ready DNA	10 ug	$559	4 weeks
RR215087	Myc-DDK-tagged ORF clone of Rattus norvegicus similar to Recombining binding protein suppressor of hairless (J kappa-recombination signal binding protein) (RBP-J kappa) (LOC679028) as transfection-ready DNA	10 ug	$559	4 weeks

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RBPJ (NM_203284) Human cDNA ORF Clone

Western Blot Validated

ORF Clones Citations:

RBPJ Mouse Clones

RBPJ Rat Clones

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