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Home cDNA Clone TrueORF All BMPR2 ORF Clones

BMPR2 (NM_001204) Human cDNA ORF Clone

Specifications Citations Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RG208673 BMPR2 (GFP-tagged) - Human bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2), 10µg
$860
In Stock
TA150041 2H8, Anti-tGFP monoclonal antibody, 100µl $248 In Stock
Clone Modification
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Also for BMPR2 (NM_001204)
cDNA Clone shRNA/siRNA Lysate Protein Antibody
TrueORF Data for RG208673
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Vector: pCMV6-AC-GFP   Change vector? Tag: C-terminal TurboGFP
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 3117 bp
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map Plasmid Map
OTI Annotation: This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Protein KinaseTransmembraneDruggable Genome
Protein Pathways: Cytokine-cytokine receptor interactionTGF-beta signaling pathway

Reference Data
RefSeq: NM_001204.5, NP_001195
RefSeq Size: 11449 RefSeq ORF: 3117
Synonyms : BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK
LocusID: 659 Cytogenetic: 2q33 Domains: Activin_recp, pkinase, TyrKc, S_TKc
Summary: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008].

 

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