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Home cDNA Clone TrueORF All PDGFB ORF Clones

PDGFB (NM_002608) Human cDNA ORF Clone

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RG206587 PDGFB (GFP-tagged) - Human platelet-derived growth factor beta polypeptide (PDGFB), transcript variant 1, 10µg   
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Also for PDGFB (NM_002608)
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TrueORF Data for RG206587
Vector: pCMV6-AC-GFP   Change vector? Tag: C-terminal TurboGFP
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 726 bp
Restriction Sites: SgfI-RsrII     Cloning Scheme for this gene     Plasmid Map Plasmid Map
OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Druggable Genome
Protein Pathways: MAPK signaling pathwayCytokine-cytokine receptor interactionFocal adhesionGap junctionRegulation of actin cytoskeletonPathways in cancerMore Pathways >>

Reference Data
RefSeq Explanation: NM_002608.1, NP_002599 RefSeq Size: 3373 RefSeq ORF: 726
Synonyms : c-sis; IBGC5; PDGF-2; PDGF2; SIS; SSV
LocusID: 5155 Cytogenetic: 22q13.1 Domains: PDGF, PDGF_N
Gene Summary: This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].


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