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Home cDNA Clone TrueORF All CASP9 ORF Clones

CASP9 (NM_001229) Human cDNA ORF Clone

Specifications Citations Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RG200635 CASP9 (GFP-tagged) - Human caspase 9, apoptosis-related cysteine peptidase (CASP9), transcript variant alpha, 10µg
$590
In Stock
TA150041 2H8, Anti-tGFP monoclonal antibody, 100µl $248 In Stock
Clone Modification
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Also for CASP9 (NM_001229)
cDNA Clone shRNA/siRNA Protein/Lysate Antibody Assay
TrueORF Data for RG200635
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Vector: pCMV6-AC-GFP   Change vector? Tag: C-terminal TurboGFP
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 1251 bp
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map Plasmid Map
OTI Annotation: This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: ProteaseStem cell - PluripotencyDruggable Genome
Protein Pathways: p53 signaling pathwayApoptosisVEGF signaling pathwayAlzheimer's diseaseParkinson's diseaseAmyotrophic lateral sclerosis (ALS)More Pathways >>
* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data
RefSeq: NM_001229.2, NP_001220
RefSeq Size: 2034 RefSeq ORF: 1251
Synonyms : APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56
LocusID: 842 Cytogenetic: 1p36.21 Domains: Peptidase_C14, CARD, CASc
Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].

 

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