LRP1 (NM_002332) Human Tagged ORF Clone

CAT#: RC218369

LRP1 (Myc-DDK-tagged)-Human low density lipoprotein receptor-related protein 1 (LRP1)

Product Images

Circular map for RC218369

• 

  Western blot validation of overexpression lysate (Cat# LY400839) using anti-DDK antibody (Cat# TA50011-100). Left: Cell lysates from un-transfected HEK293T cells; Right: Cell lysates from HEK293T cells transfected with RC218369 using transfection reagent MegaTran 2.0 (Cat# TT210002).

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: LRP1
• Synonyms: A2MR; APOER; APR; CD91; IGFBP-3R; IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC218369 representing NM_002332.
  Blue=ORF Red=Cloning site Green=Tag(s)
  
  GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG
  GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC
  ATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCC
  CCTAAGACTTGCAGCCCCAAGCAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGG
  TGCGACGGTGAGAGGGACTGCCCAGACGGATCTGACGAGGCCCCTGAGATTTGTCCACAGAGTAAGGCC
  CAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTGTGTTCCCATGTCCCGCCTCTGC
  AATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTGC
  TCTCGCCTGGGCTGCCAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGC
  TTTCAGCTTCAGGCAGATGGCAAGACCTGCAAAGATTTTGATGAGTGCTCAGTGTACGGCACCTGCAGC
  CAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTGTGTTGAAGGATACCTCCTGCAGCCGGAT
  AACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAACTCCCAG
  AACATCTTGGCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACC
  ACAGCCATGGACTTCAGCTATGCCAACGAGACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAG
  ACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAAGGGCTTCGTGGATGAGCACACCATCAACATCTCC
  CTCAGTCTGCACCACGTGGAACAGATGGCCATCGACTGGCTGACAGGCAACTTCTACTTTGTGGATGAC
  ATCGATGATAGGATCTTTGTCTGCAACAGAAATGGGGACACATGTGTCACATTGCTAGACCTGGAACTC
  TACAACCCCAAGGGCATTGCCCTGGACCCTGCCATGGGGAAGGTGTTTTTCACTGACTATGGGCAGATC
  CCAAAGGTGGAACACTGTGACATGGATGGGCAGAACCGCACCAAGCTCGTCGACAGCAAGATTGTGTTT
  CCTCATGGCATCACGCTGGACCTGGTCAGCCGCCTTGTCTACTGGGCAGATGCCTATCTGGACTATATT
  GAAGTGGTGGACTATGAGGGCAAGGGCCGCCAGACCATCATCCAGGGCATCCTGATTGAGCACCTGTAC
  GGCCTGACTGTGTTTGAGAATTATCTCTATGCCACCAACTCGGACAATGCCAATGCCCAGCAGAAGACG
  AGTGTGATCCGTGTGAACCGCTTTAACAGCACCGAGTACCAGGTTGTCACCCGGGTGGACAAGGGTGGT
  GCCCTCCACATCTACCACCAGAGGCGTCAGCCCCGAGTGAGGAGCCATGCCTGTGAAAACGACCAGTAT
  GGGAAGCCGGGTGGCTGCTCTGACATCTGCCTGCTGGCCAACAGCCACAAGGCGCGGACCTGCCGCTGC
  CGTTCCGGCTTCAGCCTGGGCAGTGACGGGAAGTCATGCAAGAAGCCGGAGCATGAGCTGTTCCTCGTG
  TATGGCAAGGGCCGGCCAGGCATCATCCGGGGCATGGATATGGGGGCCAAGGTCCCGGATGAGCACATG
  ATCCCCATTGAAAACCTCATGAACCCCCGAGCCCTGGACTTCCACGCTGAGACCGGCTTCATCTACTTT
  GCCGACACCACCAGCTACCTCATTGGCCGCCAGAAGATTGATGGCACTGAGCGGGAGACCATCCTGAAG
  GACGGCATCCACATTGTGGAGGGTGTGGCCGTGGACTGGATGGGAGACAATCTGTACTGGACGGACGAT
  GGGCCCAAAAAGACAATCAGCGTGGCCAGGCTGGAGAAAGCTGCTCAGACCCGCAAGACTTTAATCGAG
  GGCAAAATGACACACCCCAGGGCTATTGTGGTGGATCCACTCAATGGGTGGATGTACTGGACAGACTGG
  GAGGAGGACCCCAAGGACAGTCGGCGTGGGCGGCTGGAGAGGGCGTGGATGGATGGCTCACACCGAGAC
  ATCTTTGTCACCTCCAAGACAGTGCTTTGGCCCAATGGGCTAAGCCTGGACATCCCGGCTGGGCGCCTC
  TACTGGGTGGATGCCTTCTACGACCGCATCGAGACGATACTGCTCAATGGCACAGACCGGAAGATTGTG
  TATGAAGGTCCTGAGCTGAACCACGCCTTTGGCCTGTGTCACCATGGCAACTACCTCTTCTGGACTGAG
  TATCGGAGTGGCAGTGTCTACCGCTTGGAACGGGGTGTAGGAGGCGCACCCCCCACTGTGACCCTTCTG
  CGCAGTGAGCGGCCCCCCATCTTTGAGATCCGAATGTATGATGCCCAGCAGCAGCAAGTTGGCACCAAC
  AAATGCCGGGTGAACAATGGCGGCTGCAGCAGCCTGTGCTTGGCCACCCCTGGGAGCCGCCAGTGCGCC
  TGTGCTGAGGACCAGGTGTTGGACGCAGACGGCGTCACTTGCTTGGCGAACCCATCCTACGTGCCTCCA
  CCCCAGTGCCAGCCAGGCGAGTTTGCCTGTGCCAACAGCCGCTGCATCCAGGAGCGCTGGAAGTGTGAC
  GGAGACAACGATTGCCTGGACAACAGTGATGAGGCCCCAGCCCTCTGCCATCAGCACACCTGCCCCTCG
  GACCGATTCAAGTGCGAGAACAACCGGTGCATCCCCAACCGCTGGCTCTGCGACGGGGACAATGACTGT
  GGGAACAGTGAAGATGAGTCCAATGCCACTTGTTCAGCCCGCACCTGCCCCCCCAACCAGTTCTCCTGT
  GCCAGTGGCCGCTGCATCCCCATCTCCTGGACGTGTGATCTGGATGACGACTGTGGGGACCGCTCTGAT
  GAGTCTGCTTCGTGTGCCTATCCCACCTGCTTCCCCCTGACTCAGTTTACCTGCAACAATGGCAGATGT
  ATCAACATCAACTGGAGATGCGACAATGACAATGACTGTGGGGACAACAGTGACGAAGCCGGCTGCAGC
  CACTCCTGTTCTAGCACCCAGTTCAAGTGCAACAGCGGGCGTTGCATCCCCGAGCACTGGACCTGCGAT
  GGGGACAATGACTGCGGAGACTACAGTGATGAGACACACGCCAACTGCACCAACCAGGCCACGAGGCCC
  CCTGGTGGCTGCCACACTGATGAGTTCCAGTGCCGGCTGGATGGACTATGCATCCCCCTGCGGTGGCGC
  TGCGATGGGGACACTGACTGCATGGACTCCAGCGATGAGAAGAGCTGTGAGGGAGTGACCCACGTCTGC
  GATCCCAGTGTCAAGTTTGGCTGCAAGGACTCAGCTCGGTGCATCAGCAAAGCGTGGGTGTGTGATGGC
  GACAATGACTGTGAGGATAACTCGGACGAGGAGAACTGCGAGTCCCTGGCCTGCAGGCCACCCTCGCAC
  CCTTGTGCCAACAACACCTCAGTCTGCCTGCCCCCTGACAAGCTGTGTGATGGCAACGACGACTGTGGC
  GACGGCTCAGATGAGGGCGAGCTCTGTGACCAGTGCTCTCTGAATAACGGTGGCTGCAGCCACAACTGC
  TCAGTGGCACCTGGCGAAGGCATTGTGTGTTCCTGCCCTCTGGGCATGGAGCTGGGGCCCGACAACCAC
  ACCTGCCAGATCCAGAGCTACTGTGCCAAGCATCTCAAATGCAGCCAAAAGTGCGACCAGAACAAGTTC
  AGCGTGAAGTGCTCCTGCTACGAGGGCTGGGTCCTGGAACCTGACGGCGAGAGCTGCCGCAGCCTGGAC
  CCCTTCAAGCCGTTCATCATTTTCTCCAACCGCCATGAAATCCGGCGCATCGATCTTCACAAAGGAGAC
  TACAGCGTCCTGGTGCCCGGCCTGCGCAACACCATCGCCCTGGACTTCCACCTCAGCCAGAGCGCCCTC
  TACTGGACCGACGTGGTGGAGGACAAGATCTACCGCGGGAAGCTGCTGGACAACGGAGCCCTGACTAGT
  TTCGAGGTGGTGATTCAGTATGGCCTGGCCACACCCGAGGGCCTGGCTGTAGACTGGATTGCAGGCAAC
  ATCTACTGGGTGGAGAGTAACCTGGATCAGATCGAGGTGGCCAAGCTGGATGGGACCCTCCGGACCACC
  CTGCTGGCCGGTGACATTGAGCACCCAAGGGCAATCGCACTGGATCCCCGGGATGGGATCCTGTTTTGG
  ACAGACTGGGATGCCAGCCTGCCCCGCATTGAGGCAGCCTCCATGAGTGGGGCTGGGCGCCGCACCGTG
  CACCGGGAGACCGGCTCTGGGGGCTGGCCCAACGGGCTCACCGTGGACTACCTGGAGAAGCGCATCCTT
  TGGATTGACGCCAGGTCAGATGCCATTTACTCAGCCCGTTACGACGGCTCTGGCCACATGGAGGTGCTT
  CGGGGACACGAGTTCCTGTCGCACCCGTTTGCAGTGACGCTGTACGGGGGGGAGGTCTACTGGACTGAC
  TGGCGAACAAACACACTGGCTAAGGCCAACAAGTGGACCGGCCACAATGTCACCGTGGTACAGAGGACC
  AACACCCAGCCCTTTGACCTGCAGGTGTACCACCCCTCCCGCCAGCCCATGGCTCCCAATCCCTGTGAG
  GCCAATGGGGGCCAGGGCCCCTGCTCCCACCTGTGTCTCATCAACTACAACCGGACCGTGTCCTGCGCC
  TGCCCCCACCTCATGAAGCTCCACAAGGACAACACCACCTGCTATGAGTTTAAGAAGTTCCTGCTGTAC
  GCACGTCAGATGGAGATCCGAGGTGTGGACCTGGATGCTCCCTACTACAACTACATCATCTCCTTCACG
  GTGCCCGACATCGACAACGTCACAGTGCTAGACTACGATGCCCGCGAGCAGCGTGTGTACTGGTCTGAC
  GTGCGGACACAGGCCATCAAGCGGGCCTTCATCAACGGCACAGGCGTGGAGACAGTCGTCTCTGCAGAC
  TTGCCAAATGCCCACGGGCTGGCTGTGGACTGGGTCTCCCGAAACCTGTTCTGGACAAGCTATGACACC
  AATAAGAAGCAGATCAATGTGGCCCGGCTGGATGGCTCCTTCAAGAACGCAGTGGTGCAGGGCCTGGAG
  CAGCCCCATGGCCTTGTCGTCCACCCTCTGCGTGGGAAGCTCTACTGGACCGATGGTGACAACATCAGC
  ATGGCCAACATGGATGGCAGCAATCGCACCCTGCTCTTCAGTGGCCAGAAGGGCCCCGTGGGCCTGGCT
  ATTGACTTCCCTGAAAGCAAACTCTACTGGATCAGCTCCGGGAACCATACCATCAACCGCTGCAACCTG
  GATGGGAGTGGGCTGGAGGTCATCGATGCCATGCGGAGCCAGCTGGGCAAGGCCACCGCCCTGGCCATC
  ATGGGGGACAAGCTGTGGTGGGCTGATCAGGTGTCGGAAAAGATGGGCACATGCAGCAAGGCTGACGGC
  TCGGGCTCCGTGGTCCTTCGGAACAGCACCACCCTGGTGATGCACATGAAGGTCTATGACGAGAGCATC
  CAGCTGGACCATAAGGGCACCAACCCCTGCAGTGTCAACAACGGTGACTGCTCCCAGCTCTGCCTGCCC
  ACGTCAGAGACGACCCGCTCCTGCATGTGCACAGCCGGCTATAGCCTCCGGAGTGGCCAGCAGGCCTGC
  GAGGGCGTAGGTTCCTTTCTCCTGTACTCTGTGCATGAGGGAATCAGGGGAATTCCCCTGGATCCCAAT
  GACAAGTCAGATGCCCTGGTCCCAGTGTCCGGGACCTCGCTGGCTGTCGGCATCGACTTCCACGCTGAA
  AATGACACCATCTACTGGGTGGACATGGGCCTGAGCACGATCAGCCGGGCCAAGCGGGACCAGACGTGG
  CGTGAAGACGTGGTGACCAATGGCATTGGCCGTGTGGAGGGCATTGCAGTGGACTGGATCGCAGGCAAC
  ATCTACTGGACAGACCAGGGCTTTGATGTCATCGAGGTCGCCCGGCTCAATGGCTCCTTCCGCTACGTG
  GTGATCTCCCAGGGTCTAGACAAGCCCCGGGCCATCACCGTCCACCCGGAGAAAGGGTACTTGTTCTGG
  ACTGAGTGGGGTCAGTATCCGCGTATTGAGCGGTCTCGGCTAGATGGCACGGAGCGTGTGGTGCTGGTC
  AACGTCAGCATCAGCTGGCCCAACGGCATCTCAGTGGACTACCAGGATGGGAAGCTGTACTGGTGCGAT
  GCACGGACAGACAAGATTGAACGGATCGACCTGGAGACAGGTGAGAACCGCGAGGTGGTTCTGTCCAGC
  AACAACATGGACATGTTTTCAGTGTCTGTGTTTGAGGATTTCATCTACTGGAGTGACAGGACTCATGCC
  AACGGCTCTATCAAGCGCGGGAGCAAAGACAATGCCACAGACTCCGTGCCCCTGCGAACCGGCATCGGC
  GTCCAGCTTAAAGACATCAAAGTCTTCAACCGGGACCGGCAGAAAGGCACCAACGTGTGCGCGGTGGCC
  AATGGCGGGTGCCAGCAGCTGTGCCTGTACCGGGGCCGTGGGCAGCGGGCCTGCGCCTGTGCCCACGGG
  ATGCTGGCTGAAGACGGAGCATCGTGCCGCGAGTATGCCGGCTACCTGCTCTACTCAGAGCGCACCATT
  CTCAAGAGTATCCACCTGTCGGATGAGCGCAACCTCAATGCGCCCGTGCAGCCCTTCGAGGACCCTGAG
  CACATGAAGAACGTCATCGCCCTGGCCTTTGACTACCGGGCAGGCACCTCTCCGGGCACCCCCAATCGC
  ATCTTCTTCAGCGACATCCACTTTGGGAACATCCAACAGATCAACGACGATGGCTCCAGGAGGATCACC
  ATTGTGGAAAACGTGGGCTCCGTGGAAGGCCTGGCCTATCACCGTGGCTGGGACACTCTCTATTGGACA
  AGCTACACGACATCCACCATCACGCGCCACACAGTGGACCAGACCCGCCCAGGGGCCTTCGAGCGTGAG
  ACCGTCATCACTATGTCTGGAGATGACCACCCACGGGCCTTCGTTTTGGACGAGTGCCAGAACCTCATG
  TTCTGGACCAACTGGAATGAGCAGCATCCCAGCATCATGCGGGCGGCGCTCTCGGGAGCCAATGTCCTG
  ACCCTTATCGAGAAGGACATCCGTACCCCCAATGGCCTGGCCATCGACCACCGTGCCGAGAAGCTCTAC
  TTCTCTGACGCCACCCTGGACAAGATCGAGCGGTGCGAGTATGACGGCTCCCACCGCTATGTGATCCTA
  AAGTCAGAGCCTGTCCACCCCTTCGGGCTGGCCGTGTATGGGGAGCACATTTTCTGGACTGACTGGGTG
  CGGCGGGCAGTGCAGCGGGCCAACAAGCACGTGGGCAGCAACATGAAGCTGCTGCGCGTGGACATCCCC
  CAGCAGCCCATGGGCATCATCGCCGTGGCCAACGACACCAACAGCTGTGAACTCTCTCCATGCCGAATC
  AACAACGGTGGCTGCCAGGACCTGTGTCTGCTCACTCACCAGGGCCATGTCAACTGCTCATGCCGAGGG
  GGCCGAATCCTCCAGGATGACCTCACCTGCCGAGCGGTGAATTCCTCTTGCCGAGCACAAGATGAGTTT
  GAGTGTGCCAATGGCGAGTGCATCAACTTCAGCCTGACCTGCGACGGCGTCCCCCACTGCAAGGACAAG
  TCCGATGAGAAGCCATCCTACTGCAACTCCCGCCGCTGCAAGAAGACTTTCCGGCAGTGCAGCAATGGG
  CGCTGTGTGTCCAACATGCTGTGGTGCAACGGGGCCGACGACTGTGGGGATGGCTCTGACGAGATCCCT
  TGCAACAAGACAGCCTGTGGTGTGGGCGAGTTCCGCTGCCGGGACGGGACCTGCATCGGGAACTCCAGC
  CGCTGCAACCAGTTTGTGGATTGTGAGGACGCCTCAGATGAGATGAACTGCAGTGCCACCGACTGCAGC
  AGCTACTTCCGCCTGGGCGTGAAGGGCGTGCTCTTCCAGCCCTGCGAGCGGACCTCACTCTGCTACGCA
  CCCAGCTGGGTGTGTGATGGCGCCAATGACTGTGGGGACTACAGTGATGAGCGCGACTGCCCAGGTGTG
  AAACGCCCCAGATGCCCTCTGAATTACTTCGCCTGCCCTAGTGGGCGCTGCATCCCCATGAGCTGGACG
  TGTGACAAAGAGGATGACTGTGAACATGGCGAGGACGAGACCCACTGCAACAAGTTCTGCTCAGAGGCC
  CAGTTTGAGTGCCAGAACCATCGCTGCATCTCCAAGCAGTGGCTGTGTGACGGCAGCGATGACTGTGGG
  GATGGCTCAGACGAGGCTGCTCACTGTGAAGGCAAGACGTGCGGCCCCTCCTCCTTCTCCTGCCCTGGC
  ACCCACGTGTGCGTCCCCGAGCGCTGGCTCTGTGACGGTGACAAAGACTGTGCTGATGGTGCAGACGAG
  AGCATCGCAGCTGGTTGCTTGTACAACAGCACTTGTGACGACCGTGAGTTCATGTGCCAGAACCGCCAG
  TGCATCCCCAAGCACTTCGTGTGTGACCACGACCGTGACTGTGCAGATGGCTCTGATGAGTCCCCCGAG
  TGTGAGTACCCGACCTGCGGCCCCAGTGAGTTCCGCTGTGCCAATGGGCGCTGTCTGAGCTCCCGCCAG
  TGGGAGTGTGATGGCGAGAATGACTGCCACGACCAGAGTGACGAGGCTCCCAAGAACCCACACTGCACC
  AGCCAAGAGCACAAGTGCAATGCCTCGTCACAGTTCCTGTGCAGCAGTGGGCGCTGTGTGGCTGAGGCA
  CTGCTCTGCAACGGCCAGGATGACTGTGGCGACAGCTCGGACGAGCGTGGCTGCCACATCAATGAGTGT
  CTCAGCCGCAAGCTCAGTGGCTGCAGCCAGGACTGTGAGGACCTCAAGATCGGCTTCAAGTGCCGCTGT
  CGCCCTGGCTTCCGGCTGAAGGACGACGGCCGGACGTGTGCTGATGTGGACGAGTGCAGCACCACCTTC
  CCCTGCAGCCAGCGCTGCATCAACACTCATGGCAGCTATAAGTGTCTGTGTGTGGAGGGCTATGCACCC
  CGCGGCGGCGACCCCCACAGCTGCAAGGCTGTGACTGACGAGGAACCGTTTCTGATCTTCGCCAACCGG
  TACTACCTGCGCAAGCTCAACCTGGACGGGTCCAACTACACGTTACTTAAGCAGGGCCTGAACAACGCC
  GTTGCCTTGGATTTTGACTACCGAGAGCAGATGATCTACTGGACAGATGTGACCACCCAGGGCAGCATG
  ATCCGAAGGATGCACCTTAACGGGAGCAATGTGCAGGTCCTACACCGTACAGGCCTCAGCAACCCCGAT
  GGGCTGGCTGTGGACTGGGTGGGTGGCAACCTGTACTGGTGCGACAAAGGCCGGGACACCATCGAGGTG
  TCCAAGCTCAATGGGGCCTATCGGACGGTGCTGGTCAGCTCTGGCCTCCGTGAGCCCAGGGCTCTGGTG
  GTGGATGTGCAGAATGGGTACCTGTACTGGACAGACTGGGGTGACCATTCACTGATCGGCCGCATCGGC
  ATGGATGGGTCCAGCCGCAGCGTCATCGTGGACACCAAGATCACATGGCCCAATGGCCTGACGCTGGAC
  TATGTCACTGAGCGCATCTACTGGGCCGACGCCCGCGAGGACTACATTGAATTTGCCAGCCTGGATGGC
  TCCAATCGCCACGTTGTGCTGAGCCAGGACATCCCGCACATCTTTGCACTGACCCTGTTTGAGGACTAC
  GTCTACTGGACCGACTGGGAAACAAAGTCCATTAACCGAGCCCACAAGACCACGGGCACCAACAAAACG
  CTCCTCATCAGCACGCTGCACCGGCCCATGGACCTGCATGTCTTCCATGCCCTGCGCCAGCCAGACGTG
  CCCAATCACCCCTGCAAGGTCAACAATGGTGGCTGCAGCAACCTGTGCCTGCTGTCCCCCGGGGGAGGG
  CACAAATGTGCCTGCCCCACCAACTTCTACCTGGGCAGCGATGGGCGCACCTGTGTGTCCAACTGCACG
  GCTAGCCAGTTTGTATGCAAGAACGACAAGTGCATCCCCTTCTGGTGGAAGTGTGACACCGAGGACGAC
  TGCGGGGACCACTCAGACGAGCCCCCGGACTGCCCTGAGTTCAAGTGCCGGCCCGGACAGTTCCAGTGC
  TCCACAGGTATCTGCACAAACCCTGCCTTCATCTGCGATGGCGACAATGACTGCCAGGACAACAGTGAC
  GAGGCCAACTGTGACATCCACGTCTGCTTGCCCAGTCAGTTCAAATGCACCAACACCAACCGCTGTATT
  CCCGGCATCTTCCGCTGCAATGGGCAGGACAACTGCGGAGATGGGGAGGATGAGAGGGACTGCCCCGAG
  GTGACCTGCGCCCCCAACCAGTTCCAGTGCTCCATTACCAAACGGTGCATCCCCCGGGTCTGGGTCTGC
  GACCGGGACAATGACTGTGTGGATGGCAGTGATGAGCCCGCCAACTGCACCCAGATGACCTGTGGTGTG
  GACGAGTTCCGCTGCAAGGATTCGGGCCGCTGCATCCCAGCGCGTTGGAAGTGTGACGGAGAGGATGAC
  TGTGGGGATGGCTCGGATGAGCCCAAGGAAGAGTGTGATGAACGCACCTGTGAGCCATACCAGTTCCGC
  TGCAAGAACAACCGCTGCGTGCCCGGCCGCTGGCAGTGCGACTACGACAACGATTGCGGTGACAACTCC
  GATGAAGAGAGCTGCACCCCTCGGCCCTGCTCCGAGAGTGAGTTCTCCTGTGCCAACGGCCGCTGCATC
  GCGGGGCGCTGGAAATGCGATGGAGACCACGACTGCGCGGACGGCTCGGACGAGAAAGACTGCACCCCC
  CGCTGTGACATGGACCAGTTCCAGTGCAAGAGCGGCCACTGCATCCCCCTGCGCTGGCGCTGTGACGCA
  GACGCCGACTGCATGGACGGCAGCGACGAGGAGGCCTGCGGCACTGGCGTGCGGACCTGCCCCCTGGAC
  GAGTTCCAGTGCAACAACACCTTGTGCAAGCCGCTGGCCTGGAAGTGCGATGGCGAGGATGACTGTGGG
  GACAACTCAGATGAGAACCCCGAGGAGTGTGCCCGGTTCGTGTGCCCTCCCAACCGGCCCTTCCGTTGC
  AAGAATGACCGCGTCTGTCTGTGGATCGGGCGCCAATGCGATGGCACGGACAACTGTGGGGATGGGACT
  GATGAAGAGGACTGTGAGCCCCCCACAGCCCACACCACCCACTGCAAAGACAAGAAGGAGTTTCTGTGC
  CGGAACCAGCGCTGCCTCTCCTCCTCCCTGCGCTGCAACATGTTCGATGACTGCGGGGACGGCTCTGAC
  GAGGAGGACTGCAGCATCGACCCCAAGCTGACCAGCTGCGCCACCAATGCCAGCATCTGTGGGGACGAG
  GCACGCTGCGTGCGCACCGAGAAAGCGGCCTACTGTGCCTGCCGCTCGGGCTTCCACACCGTGCCCGGC
  CAGCCCGGATGCCAAGACATCAACGAGTGCCTGCGCTTCGGCACCTGCTCCCAGCTCTGCAACAACACC
  AAGGGCGGCCACCTCTGCAGCTGCGCTCGGAACTTCATGAAGACGCACAACACCTGCAAGGCCGAAGGC
  TCTGAGTACCAGGTCCTGTACATCGCTGATGACAATGAGATCCGCAGCCTGTTCCCCGGCCACCCCCAT
  TCGGCTTACGAGCAGGCATTCCAGGGTGACGAGAGTGTCCGCATTGATGCTATGGATGTCCATGTCAAG
  GCTGGCCGTGTCTATTGGACCAACTGGCACACGGGCACCATCTCCTACCGCAGCCTGCCACCTGCTGCG
  CCTCCTACCACTTCCAACCGCCACCGGCGACAGATTGACCGGGGTGTCACCCACCTCAACATTTCAGGG
  CTGAAGATGCCCAGAGGCATCGCCATCGACTGGGTGGCCGGAAACGTGTACTGGACCGACTCGGGCCGA
  GATGTGATTGAGGTGGCGCAGATGAAGGGCGAGAACCGCAAGACGCTCATCTCGGGCATGATTGACGAG
  CCCCACGCCATTGTGGTGGACCCACTGAGGGGGACCATGTACTGGTCAGACTGGGGCAACCACCCCAAG
  ATTGAGACGGCAGCGATGGATGGGACGCTTCGGGAGACACTGGTGCAGGACAACATTCAGTGGCCCACA
  GGCCTGGCCGTGGATTATCACAATGAGCGGCTGTACTGGGCAGACGCCAAGCTTTCAGTCATCGGCAGC
  ATCCGGCTCAATGGCACGGACCCCATTGTGGCTGCTGACAGCAAACGAGGCCTAAGTCACCCCTTCAGC
  ATCGACGTCTTTGAGGATTACATCTATGGTGTCACCTACATCAATAATCGTGTCTTCAAGATCCATAAG
  TTTGGCCACAGCCCCTTGGTCAACCTGACAGGGGGCCTGAGCCACGCCTCTGACGTGGTCCTTTACCAT
  CAGCACAAGCAGCCCGAAGTGACCAACCCATGTGACCGCAAGAAATGCGAGTGGCTCTGCCTGCTGAGC
  CCCAGTGGGCCTGTCTGCACCTGTCCCAATGGGAAGCGGCTGGACAACGGCACATGCGTGCCTGTGCCC
  TCTCCAACGCCCCCCCCAGATGCTCCCCGGCCTGGAACCTGTAACCTGCAGTGCTTCAACGGTGGCAGC
  TGTTTCCTCAATGCACGGAGGCAGCCCAAGTGCCGCTGCCAACCCCGCTACACGGGTGACAAGTGTGAA
  CTGGACCAGTGCTGGGAGCACTGTCGCAATGGGGGCACCTGTGCTGCCTCCCCCTCTGGCATGCCCACG
  TGCCGGTGCCCCACGGGCTTCACGGGCCCCAAATGCACCCAGCAGGTGTGTGCGGGCTACTGTGCCAAC
  AACAGCACCTGCACTGTCAACCAGGGCAACCAGCCCCAGTGCCGATGCCTACCCGGCTTCCTGGGCGAC
  CGCTGCCAGTACCGGCAGTGCTCTGGCTACTGTGAGAACTTTGGCACATGCCAGATGGCTGCTGATGGC
  TCCCGACAATGCCGCTGCACTGCCTACTTTGAGGGATCGAGGTGTGAGGTGAACAAGTGCAGCCGCTGT
  CTCGAAGGGGCCTGTGTGGTCAACAAGCAGAGTGGGGATGTCACCTGCAACTGCACGGATGGCCGGGTG
  GCCCCCAGCTGTCTGACCTGCGTCGGCCACTGCAGCAATGGCGGCTCCTGTACCATGAACAGCAAAATG
  ATGCCTGAGTGCCAGTGCCCACCCCACATGACAGGGCCCCGGTGTGAGGAGCACGTCTTCAGCCAGCAG
  CAGCCAGGACATATAGCCTCCATCCTAATCCCTCTGCTGTTGCTGCTGCTGCTGGTTCTGGTGGCCGGA
  GTGGTATTCTGGTATAAGCGGCGAGTCCAAGGGGCTAAGGGCTTCCAGCACCAACGGATGACCAACGGG
  GCCATGAACGTGGAGATTGGAAACCCCACCTACAAGATGTACGAAGGCGGAGAGCCTGATGATGTGGGA
  GGCCTACTGGACGCTGACTTTGCCCTGGACCCTGACAAGCCCACCAACTTCACCAACCCCGTGTATGCC
  ACACTCTACATGGGGGGCCATGGCAGTCGCCACTCCCTGGCCAGCACGGACGAGAAGCGAGAACTCCTG
  GGCCGGGGCCCTGAGGACGAGATAGGGGACCCCTTGGCA
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT
  TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC
  
  Protein Sequence

  >Peptide sequence encoded by RC218369
  Blue=ORF Red=Cloning site Green=Tag(s)
  
  MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKA
  QRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSS
  FQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQ
  NILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINIS
  LSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQI
  PKVEHCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLY
  GLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQY
  GKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHM
  IPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHIVEGVAVDWMGDNLYWTDD
  GPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRD
  IFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTE
  YRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCA
  CAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPS
  DRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSD
  ESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCD
  GDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVC
  DPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCG
  DGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKF
  SVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSAL
  YWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTT
  LLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRIL
  WIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRT
  NTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLY
  ARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSAD
  LPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNIS
  MANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAI
  MGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLP
  TSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAE
  NDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYV
  VISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCD
  ARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIG
  VQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTI
  LKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRIT
  IVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLM
  FWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVIL
  KSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRI
  NNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDK
  SDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSS
  RCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGV
  KRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCG
  DGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQ
  CIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCT
  SQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRC
  RPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANR
  YYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPD
  GLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIG
  MDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDY
  VYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGG
  HKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQC
  STGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPE
  VTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDD
  CGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCI
  AGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLD
  EFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGT
  DEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDE
  ARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEG
  SEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAA
  PPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDE
  PHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGS
  IRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYH
  QHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGS
  CFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCAN
  NSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRC
  LEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQ
  QPGHIASILIPLLLLLLLVLVAGVVFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVG
  GLLDADFALDPDKPTNFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
  
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_002332
• ORF Size: 13632 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002332.3
• RefSeq Size: 14896 bp
• RefSeq ORF: 13635 bp
• Locus ID: 4035
• UniProt ID: Q07954
• Cytogenetics: 12q13.3
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Alzheimer's disease
• MW: 504.6 kDa
• Gene Summary: This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]