OriGene - CFLAR (NM_001127184) Human ORF cDNA Clone

Western Blot Validated

TrueORF Data for RG225270

Vector:	pCMV6-AC-GFP Change vector?	Tag: C-terminal TurboGFP	Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Sequence Data:	ORF Nucleotide Sequence CHROMATOGRAMS Protein Sequence	ORF Size: 666 bp Predicted Protein MW: 25.2 kDa
Restriction Sites:	SgfI-MluI Cloning Scheme for this gene Plasmid Map
OTI Annotation:	This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer:	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components:	The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families:	Protease Druggable Genome
Protein Pathways:	Apoptosis

* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data

RefSeq: NM_001127184.1, NP_001120656	RefSeq Size:	RefSeq ORF: 666
Synonyms : c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
LocusID: 8837	Cytogenetic: 2q33
Summary: The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011].

ORF Clones Citations:

Solute Carrier 11A1 Is Expressed by Innate Lymphocytes and Augments Their Activation, Jodi F. Hedges, Emily Kimmel, Deann T. Snyder, Maria Jerome, and Mark A. Jutila, J. Immunol., Apr 2013; 190: 4263 - 4273. [SLC11A1]

A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function, Feng Gao, Hansel E. Ihn, Marisa W. Medina, and Ronald M. Krauss, Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [LDLR]

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP, Lisa Muniz, Sylvain Egloff, and Tamás Kiss, Nucleic Acids Res., Apr 2013; 41: 4686 - 4698. [MEPCE ]

Structural basis for angiopoietin-1–mediated signaling initiation, Xuehong Yu, Tom C. M. Seegar, Annamarie C. Dalton, Dorothea Tzvetkova-Robev, Yehuda Goldgur, Kanagalaghatta R. Rajashankar, Dimitar B. Nikolov, and William A. Barton, PNAS, Apr 2013; 110: 7205 - 7210. [ANGPT1]

Inverted Formin 2 Regulates Actin Dynamics by Antagonizing Rho/Diaphanous-related Formin Signaling, Hua Sun, Johannes Schlondorff, Henry N. Higgs, and Martin R. Pollak, J. Am. Soc. Nephrol., Apr 2013; 10.1681/ASN.2012080834. [INF2]

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway, Chutima Kumkhaek, Wulin Aerbajinai, Wenli Liu, Jianqiong Zhu, Naoya Uchida, Roger Kurlander, Matthew M. Hsieh, John F. Tisdale, and Griffin P. Rodgers, Blood, Apr 2013; 121: 3216 - 3227. [MFHAS1 ]

Proximal tubule-dominant transfer of AT1a receptors induces blood pressure responses to intracellular angiotensin II in AT1a receptor-deficient mice, Xiao C. Li and Jia L. Zhuo, Am J Physiol Regulatory Integrative Comp Physiol, Apr 2013; 304: R588 - R598. [AGTR1A ]

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase, Pardeep Heir, Roxana I. Sufan, Samantha N. Greer, Betty P. Poon, Jeffrey E. Lee, and Michael Ohh, Mol. Cell. Biol., Apr 2013; 33: 1621 - 1631. [DCNL1]

More TrueClone Citations >>

CFLAR Mouse Clones

SKU	Description	Amount	Price	Shipping
MC208280	Mus musculus CASP8 and FADD-like apoptosis regulator (Cflar), transcript variant 2 as transfection-ready DNA	10 ug	$380	Next day
MC216618	Mus musculus CASP8 and FADD-like apoptosis regulator (Cflar), transcript variant 1 as transfection-ready DNA	10 ug	$580	3 weeks
MC207022	Mus musculus CASP8 and FADD-like apoptosis regulator (cDNA clone MGC:28609 IMAGE:4218551) as transfection-ready DNA	10 ug	$300	Next day
MR222341	Myc-DDK-tagged ORF clone of Mus musculus CASP8 and FADD-like apoptosis regulator (Cflar), transcript variant 2 as transfection-ready DNA	10 ug	$380	3 weeks
MR222986	Myc-DDK-tagged ORF clone of Mus musculus CASP8 and FADD-like apoptosis regulator (Cflar), transcript variant 1 as transfection-ready DNA	10 ug	$580	3 weeks
MR200009	Myc-DDK-tagged ORF clone of Mus musculus CASP8 and FADD-like apoptosis regulator (cDNA clone MGC:28609 IMAGE:4218551) as transfection-ready DNA	10 ug	$300	Next day
MG222341	GFP-tagged ORF clone of Mus musculus CASP8 and FADD-like apoptosis regulator (Cflar) transcript variant 2 as transfection-ready DNA	10 ug	$420	3 weeks
MG222986	GFP-tagged ORF clone of Mus musculus CASP8 and FADD-like apoptosis regulator (Cflar) transcript variant 1 as transfection-ready DNA	10 ug	$640	3 weeks
MG200009	GFP-tagged ORF clone of Mus musculus CASP8 and FADD-like apoptosis regulator (cDNA clone MGC:28609 IMAGE:4218551) in a GFP expression vector	10 ug	$330	3 weeks

CFLAR Rat Clones

SKU	Description	Amount	Price	Shipping
RN200219	NativeORF clone of Rattus norvegicus CASP8 and FADD-like apoptosis regulator (Cflar), transcript variant 1 as transfection-ready DNA	10 ug	$577	4 weeks
RN200220	NativeORF clone of Rattus norvegicus CASP8 and FADD-like apoptosis regulator (Cflar), transcript variant 2 as transfection-ready DNA	10 ug	$380	4 weeks
RR200219	Myc-DDK-tagged ORF clone of Rattus norvegicus CASP8 and FADD-like apoptosis regulator (Cflar), transcript variant 1 as transfection-ready DNA	10 ug	$577	Next day
RR200220	Myc-DDK-tagged ORF clone of Rattus norvegicus CASP8 and FADD-like apoptosis regulator (Cflar), transcript variant 2 as transfection-ready DNA	10 ug	$380	Next day

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CFLAR (NM_001127184) Human cDNA ORF Clone

Western Blot Validated

ORF Clones Citations:

CFLAR Mouse Clones

CFLAR Rat Clones

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