OriGene - WHSC1 (NM_133335) Human ORF cDNA Clone

Western Blot Validated

TrueORF Data for RG223174

Vector:	pCMV6-AC-GFP Change vector?	Tag: C-terminal TurboGFP	Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Sequence Data:	ORF Nucleotide Sequence CHROMATOGRAMS Protein Sequence	ORF Size: 4098 bp Predicted Protein MW: 152.1 kDa
Restriction Sites:	SgfI-MluI Cloning Scheme for this gene Plasmid Map
OTI Annotation:	This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer:	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components:	The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families:	Transcription Factors Druggable Genome
Protein Pathways:	Lysine degradation

* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data

RefSeq: NM_133335.3, NP_579890	RefSeq Size: 7530	RefSeq ORF: 4098
Synonyms : MMSET; NSD2; REIIBP; TRX5; WHS
LocusID: 7468	Cytogenetic: 4p16.3	Domains: PWWP, HMG, SET, PHD, PostSET, AWS
Summary: This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008].

ORF Clones Citations:

Solute Carrier 11A1 Is Expressed by Innate Lymphocytes and Augments Their Activation, Jodi F. Hedges, Emily Kimmel, Deann T. Snyder, Maria Jerome, and Mark A. Jutila, J. Immunol., Apr 2013; 190: 4263 - 4273. [SLC11A1]

A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function, Feng Gao, Hansel E. Ihn, Marisa W. Medina, and Ronald M. Krauss, Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [LDLR]

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP, Lisa Muniz, Sylvain Egloff, and Tamás Kiss, Nucleic Acids Res., Apr 2013; 41: 4686 - 4698. [MEPCE ]

Structural basis for angiopoietin-1–mediated signaling initiation, Xuehong Yu, Tom C. M. Seegar, Annamarie C. Dalton, Dorothea Tzvetkova-Robev, Yehuda Goldgur, Kanagalaghatta R. Rajashankar, Dimitar B. Nikolov, and William A. Barton, PNAS, Apr 2013; 110: 7205 - 7210. [ANGPT1]

Inverted Formin 2 Regulates Actin Dynamics by Antagonizing Rho/Diaphanous-related Formin Signaling, Hua Sun, Johannes Schlondorff, Henry N. Higgs, and Martin R. Pollak, J. Am. Soc. Nephrol., Apr 2013; 10.1681/ASN.2012080834. [INF2]

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway, Chutima Kumkhaek, Wulin Aerbajinai, Wenli Liu, Jianqiong Zhu, Naoya Uchida, Roger Kurlander, Matthew M. Hsieh, John F. Tisdale, and Griffin P. Rodgers, Blood, Apr 2013; 121: 3216 - 3227. [MFHAS1 ]

Proximal tubule-dominant transfer of AT1a receptors induces blood pressure responses to intracellular angiotensin II in AT1a receptor-deficient mice, Xiao C. Li and Jia L. Zhuo, Am J Physiol Regulatory Integrative Comp Physiol, Apr 2013; 304: R588 - R598. [AGTR1A ]

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase, Pardeep Heir, Roxana I. Sufan, Samantha N. Greer, Betty P. Poon, Jeffrey E. Lee, and Michael Ohh, Mol. Cell. Biol., Apr 2013; 33: 1621 - 1631. [DCNL1]

More TrueClone Citations >>

WHSC1 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC220109	Mus musculus Wolf-Hirschhorn syndrome candidate 1 (human) (Whsc1), transcript variant 3 as transfection-ready DNA	10 ug	$780	4 weeks
MC224344	Mus musculus Wolf-Hirschhorn syndrome candidate 1 (human) (Whsc1), transcript variant 1 as transfection-ready DNA	10 ug	$1640	7 weeks
MC224345	Mus musculus Wolf-Hirschhorn syndrome candidate 1 (human) (Whsc1), transcript variant 2 as transfection-ready DNA	10 ug	$1640	7 weeks
MR219815	Myc-DDK-tagged ORF clone of Mus musculus Wolf-Hirschhorn syndrome candidate 1 (human) (Whsc1), transcript variant 1 as transfection-ready DNA	10 ug	$1640	7 weeks
MR219816	Myc-DDK-tagged ORF clone of Mus musculus Wolf-Hirschhorn syndrome candidate 1 (human) (Whsc1), transcript variant 2 as transfection-ready DNA	10 ug	$1640	7 weeks
MR219817	Myc-DDK-tagged ORF clone of Mus musculus Wolf-Hirschhorn syndrome candidate 1 (human) (Whsc1), transcript variant 3 as transfection-ready DNA	10 ug	$780	4 weeks
MG219815	GFP-tagged ORF clone of Mus musculus Wolf-Hirschhorn syndrome candidate 1 (human) (Whsc1) transcript variant 1 as transfection-ready DNA	10 ug	$1800	6 weeks
MG219816	GFP-tagged ORF clone of Mus musculus Wolf-Hirschhorn syndrome candidate 1 (human) (Whsc1) transcript variant 2 as transfection-ready DNA	10 ug	$1800	6 weeks
MG219817	GFP-tagged ORF clone of Mus musculus Wolf-Hirschhorn syndrome candidate 1 (human) (Whsc1) transcript variant 3 as transfection-ready DNA	10 ug	$860	3 weeks

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WHSC1 (NM_133335) Human cDNA ORF Clone

Western Blot Validated

ORF Clones Citations:

WHSC1 Mouse Clones

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