OriGene - PIK3C2A (NM_002645) Human ORF cDNA Clone

Western Blot Validated

The same insert cloned in a GFP-tagging vector is also available

Cat. No.	Description	Vector	Price	Availability
RG222192	GFP-tagged ORF clone of Homo sapiens phosphoinositide-3-kinase, class 2, alpha polypeptide (PIK3C2A) as transfection-ready DNA	pCMV6-AC-GFP	$2070	In Stock
TA150041	2H8, Anti-tGFP monoclonal antibody, 100µl		$248	In Stock

TrueORF Data for RC222192

Vector:	pCMV6-Entry Change vector?	Tag: C-terminal Myc-DDK	Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Sequence Data:	ORF Nucleotide Sequence CHROMATOGRAMS Protein Sequence	ORF Size: 5061 bp Predicted Protein MW: 190.5 kDa
Restriction Sites:	SgfI-MluI Cloning Scheme for this gene Plasmid Map
OTI Annotation:	This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer:	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components:	The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families:	Druggable Genome
Protein Pathways:	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system

* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data

RefSeq: NM_002645.1, NP_002636	RefSeq Size: 5061	RefSeq ORF: 5061
Synonyms : CPK; PI3-K-C2(ALPHA); PI3-K-C2A
LocusID: 5286	Cytogenetic: 11p15.5	Domains: C2, PI3K_rbd, PI3Kc, PI3Ka, PX, PI3K_C2
Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008].

ORF Clones Citations:

Solute Carrier 11A1 Is Expressed by Innate Lymphocytes and Augments Their Activation, Jodi F. Hedges, Emily Kimmel, Deann T. Snyder, Maria Jerome, and Mark A. Jutila, J. Immunol., Apr 2013; 190: 4263 - 4273. [SLC11A1]

A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function, Feng Gao, Hansel E. Ihn, Marisa W. Medina, and Ronald M. Krauss, Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [LDLR]

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP, Lisa Muniz, Sylvain Egloff, and Tamás Kiss, Nucleic Acids Res., Apr 2013; 41: 4686 - 4698. [MEPCE ]

Structural basis for angiopoietin-1–mediated signaling initiation, Xuehong Yu, Tom C. M. Seegar, Annamarie C. Dalton, Dorothea Tzvetkova-Robev, Yehuda Goldgur, Kanagalaghatta R. Rajashankar, Dimitar B. Nikolov, and William A. Barton, PNAS, Apr 2013; 110: 7205 - 7210. [ANGPT1]

Inverted Formin 2 Regulates Actin Dynamics by Antagonizing Rho/Diaphanous-related Formin Signaling, Hua Sun, Johannes Schlondorff, Henry N. Higgs, and Martin R. Pollak, J. Am. Soc. Nephrol., Apr 2013; 10.1681/ASN.2012080834. [INF2]

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway, Chutima Kumkhaek, Wulin Aerbajinai, Wenli Liu, Jianqiong Zhu, Naoya Uchida, Roger Kurlander, Matthew M. Hsieh, John F. Tisdale, and Griffin P. Rodgers, Blood, Apr 2013; 121: 3216 - 3227. [MFHAS1 ]

Proximal tubule-dominant transfer of AT1a receptors induces blood pressure responses to intracellular angiotensin II in AT1a receptor-deficient mice, Xiao C. Li and Jia L. Zhuo, Am J Physiol Regulatory Integrative Comp Physiol, Apr 2013; 304: R588 - R598. [AGTR1A ]

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase, Pardeep Heir, Roxana I. Sufan, Samantha N. Greer, Betty P. Poon, Jeffrey E. Lee, and Michael Ohh, Mol. Cell. Biol., Apr 2013; 33: 1621 - 1631. [DCNL1]

More TrueClone Citations >>

PIK3C2A Mouse Clones

SKU	Description	Amount	Price	Shipping
MC224824	Mus musculus phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Pik3c2a) as transfection-ready DNA	10 ug	$2530	7 weeks
MR215684	Myc-DDK-tagged ORF clone of Mus musculus phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Pik3c2a) as transfection-ready DNA	10 ug	$2530	7 weeks
MG215684	GFP-tagged ORF clone of Mus musculus phosphatidylinositol 3-kinase C2 domain containing alpha polypeptide (Pik3c2a) as transfection-ready DNA	10 ug	$2780	8 weeks

PIK3C2A Rat Clones

SKU	Description	Amount	Price	Shipping
RN205077	NativeORF clone of Rattus norvegicus phosphoinositide-3-kinase, class 2, alpha polypeptide (Pik3c2a) as transfection-ready DNA	10 ug	$3038	7 weeks
RR205077	Myc-DDK-tagged ORF clone of Rattus norvegicus phosphoinositide-3-kinase, class 2, alpha polypeptide (Pik3c2a) as transfection-ready DNA	10 ug	$3038	7 weeks

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PIK3C2A (NM_002645) Human cDNA ORF Clone

Western Blot Validated

ORF Clones Citations:

PIK3C2A Mouse Clones

PIK3C2A Rat Clones

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