OriGene - TADA3 (NM_006354) Human ORF cDNA Clone

Western Blot Validated

The same insert cloned in Lenti and other vectors is also available.

Cat. No.	Description	Vector	Price	Availability
RC203687L1	Lenti ORF clone of Human transcriptional adaptor 3 (TADA3), transcript variant 1 , Myc-DDK-tagged	pLenti-C-Myc-DDK pLenti-C-mGFP pCMV6-AC-GFP	$910	2 Weeks
TR30022	Lenti-vpak packaging kit - packaging plasmids and transfection reagent (10 rxns)		$360	In Stock

TrueORF Data for RC203687

Vector:	pCMV6-Entry Change vector?	Tag: C-terminal Myc-DDK	Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Sequence Data:	ORF Nucleotide Sequence CHROMATOGRAMS Protein Sequence	ORF Size: 1299 bp Predicted Protein MW: 48.7 kDa
Restriction Sites:	SgfI-MluI Cloning Scheme for this gene Plasmid Map
OTI Annotation:	This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer:	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components:	The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families:	Transcription Factors
Protein Pathways:

* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data

RefSeq: NM_006354.2, NP_006345	RefSeq Size: 2245	RefSeq ORF: 1299
Synonyms : ADA3; hADA3; NGG1; TADA3L
LocusID: 10474	Cytogenetic: 3p25.3
Summary: Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008].

ORF Clones Citations:

Solute Carrier 11A1 Is Expressed by Innate Lymphocytes and Augments Their Activation, Jodi F. Hedges, Emily Kimmel, Deann T. Snyder, Maria Jerome, and Mark A. Jutila, J. Immunol., Apr 2013; 190: 4263 - 4273. [SLC11A1]

A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function, Feng Gao, Hansel E. Ihn, Marisa W. Medina, and Ronald M. Krauss, Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [LDLR]

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP, Lisa Muniz, Sylvain Egloff, and Tamás Kiss, Nucleic Acids Res., Apr 2013; 41: 4686 - 4698. [MEPCE ]

Structural basis for angiopoietin-1–mediated signaling initiation, Xuehong Yu, Tom C. M. Seegar, Annamarie C. Dalton, Dorothea Tzvetkova-Robev, Yehuda Goldgur, Kanagalaghatta R. Rajashankar, Dimitar B. Nikolov, and William A. Barton, PNAS, Apr 2013; 110: 7205 - 7210. [ANGPT1]

Inverted Formin 2 Regulates Actin Dynamics by Antagonizing Rho/Diaphanous-related Formin Signaling, Hua Sun, Johannes Schlondorff, Henry N. Higgs, and Martin R. Pollak, J. Am. Soc. Nephrol., Apr 2013; 10.1681/ASN.2012080834. [INF2]

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway, Chutima Kumkhaek, Wulin Aerbajinai, Wenli Liu, Jianqiong Zhu, Naoya Uchida, Roger Kurlander, Matthew M. Hsieh, John F. Tisdale, and Griffin P. Rodgers, Blood, Apr 2013; 121: 3216 - 3227. [MFHAS1 ]

Proximal tubule-dominant transfer of AT1a receptors induces blood pressure responses to intracellular angiotensin II in AT1a receptor-deficient mice, Xiao C. Li and Jia L. Zhuo, Am J Physiol Regulatory Integrative Comp Physiol, Apr 2013; 304: R588 - R598. [AGTR1A ]

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase, Pardeep Heir, Roxana I. Sufan, Samantha N. Greer, Betty P. Poon, Jeffrey E. Lee, and Michael Ohh, Mol. Cell. Biol., Apr 2013; 33: 1621 - 1631. [DCNL1]

More TrueClone Citations >>

TADA3 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC202138	Mus musculus transcriptional adaptor 3 (Tada3) as transfection-ready DNA	10 ug	$165	Next day
MR206884	Myc-DDK-tagged ORF clone of Mus musculus transcriptional adaptor 3 (Tada3) as transfection-ready DNA	10 ug	$380	Next day
MG206884	GFP-tagged ORF clone of Mus musculus transcriptional adaptor 3 (NGG1 homolog, yeast)-like (Tada3l) in a GFP expression vector	10 ug	$420	3 weeks

TADA3 Rat Clones

SKU	Description	Amount	Price	Shipping
RN213222	NativeORF clone of Rattus norvegicus transcriptional adaptor 3 (NGG1 homolog, yeast)-like (Tada3l) as transfection-ready DNA	10 ug	$380	4 weeks
RR213222	Myc-DDK-tagged ORF clone of Rattus norvegicus transcriptional adaptor 3 (NGG1 homolog, yeast)-like (Tada3l) as transfection-ready DNA	10 ug	$380	4 weeks

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Use Blue Heron gene synthesis and make clone in any of OriGene's expression vectors.

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TADA3 (NM_006354) Human cDNA ORF Clone

Western Blot Validated

ORF Clones Citations:

TADA3 Mouse Clones

TADA3 Rat Clones

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