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Home cDNA Clone TrueORF All HEXA ORF Clones
TrueORF Gold

HEXA (NM_000520) Human cDNA ORF Clone

Specifications Citations Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RC203185 HEXA (Myc-DDK-tagged)-Human hexosaminidase A (alpha polypeptide) (HEXA), 10µg   
In Stock
RG203185 HEXA (GFP-tagged) - Human hexosaminidase A (alpha polypeptide) (HEXA), (10ug) $610 In Stock
TA50011-100 4C5, Anti-DDK monoclonal antibody, 100µl $248 In Stock
Cat. No. Description Price Availability
RC503185 HEXA (Myc-DDK-tagged)-Human hexosaminidase A (alpha polypeptide) (HEXA), (200ug) $680 2 weeks
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Clone Modification

The same insert cloned in Lenti and other vectors are also available.

Cat. No. Description Vector Price Availability  
RC203185L1 Lenti ORF clone of Human hexosaminidase A (alpha polypeptide) (HEXA) , Myc-DDK-tagged

$740 In Stock
TR30022 Lenti-vpak packaging kit - packaging plasmids and transfection reagent (10 rxns) Lenti-vpak-app-guide $390 In Stock
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TrueORF Data for RC203185
Vector: pCMV6-Entry   Change vector? Tag: C-terminal Myc-DDK
Western validation with an anti-DDK antibody *
L: Control HEK293 lysate
R: Over-expression lysate
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 1590 bp
Predicted Protein MW: 60.69 kDa
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map Plasmid Map
OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Druggable Genome
Protein Pathways: Other glycan degradationAmino sugar and nucleotide sugar metabolismGlycosaminoglycan degradationGlycosphingolipid biosynthesis - globo seriesGlycosphingolipid biosynthesis - ganglio seriesMetabolic pathwaysMore Pathways >>
* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data
RefSeq Explanation: NM_000520.3, NP_000511 RefSeq Size: 2320 RefSeq ORF: 1590
Synonyms : TSD
LocusID: 3073 Cytogenetic: 15q24.1 Domains: Glyco_hydro_20
Gene Summary: This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].


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