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Home cDNA Clone TrueORF All HEXA ORF Clones
TrueORF Gold

HEXA (NM_000520) Human cDNA ORF Clone

Specifications Citations Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RC203185 HEXA (Myc-DDK-tagged)-Human hexosaminidase A (alpha polypeptide) (HEXA), 10µg
$540
In Stock
RC503185 HEXA (Myc-DDK-tagged)-Human hexosaminidase A (alpha polypeptide) (HEXA), (200ug) $660 2~3 weeks
TA50011-100 4C5, Anti-DDK monoclonal antibody, 100µl $248 In Stock
Clone Modification

The same insert cloned in Lenti and other vectors is also available.

Cat. No. Description Vector Price Availability  
RC203185L2 Lenti ORF clone of Human hexosaminidase A (alpha polypeptide) (HEXA), mGFP tagged

1000 3 Weeks
TR30022 Lenti-vpak packaging kit - packaging plasmids and transfection reagent (10 rxns) Lenti-vpak-app-guide $390 In Stock
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Also for HEXA (NM_000520)
cDNA Clone shRNA/siRNA Lysate Protein Antibody
TrueORF Data for RC203185
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Vector: pCMV6-Entry   Change vector? Tag: C-terminal Myc-DDK
Western validation with an anti-DDK antibody *
L: Control HEK293 lysate
R: Over-expression lysate
Lysate_Image
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 1590 bp
Predicted Protein MW: 58.3 kDa
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map Plasmid Map
OTI Annotation: This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Druggable Genome
Protein Pathways: Other glycan degradationAmino sugar and nucleotide sugar metabolismGlycosaminoglycan degradationGlycosphingolipid biosynthesis - globo seriesGlycosphingolipid biosynthesis - ganglio seriesMetabolic pathwaysMore Pathways >>
* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data
RefSeq: NM_000520.3, NP_000511
RefSeq Size: 2320 RefSeq ORF: 1590
Synonyms : TSD
LocusID: 3073 Cytogenetic: 15q24.1 Domains: Glyco_hydro_20
Summary: This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq, Jul 2009].

 

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