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Home Gene of the month LGR5

LGR5 - Adult Stem Cell Marker

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LGR5 (leucine-rich repeat-containing G-protein-coupled receptor 5, also known as GPR49) is an orphan G-protein coupled receptor, and a target of the Wnt signaling pathway. This membrane protein is expressed in the eye, brain, hair follicle, mammary gland, reproductive organs, stomach and intestinal tract. LGR5 is closely related to tumorgenesis and is found active in various types of cancer, including colorectal, liver and ovarian cancer. Although its function is unclear, LGR5 is considered as a stem cell marker, especially for the tissues of intestine, colon, stomach and hair follicle.

OriGene has developed the world’s first mouse monoclonal antibody against LGR5 for flow cytometry. In addition, OriGene offers:

LGR5 Fig1 LGR5 Fig2 LGR5 Fig3
Detection of human LGR5 overexpreed in HEK293 cells IHC staining of paraffin-embedded human colon tissue using anti-LGR5 mAb Detection of the endogenous expression of LGR5 in HT29 cells (human colon adenocarcinoma grade II cells by flow cytometry

OriGene products of LGR5:

  1. ORF clones of human LGR5 untagged or tagged with Myc-DDK/GFP
  2. ORF clones of mouse LGR5 untagged or tagged with Myc-DDK/GFP
  3. LGR5 over-expression cell lysate as positive control

Reference:

  • N. Barker, et. al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) Oct 25;449(7165):1003-7.

View all LGR5 products offering from OriGene >>

 

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