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OriGene Antibodies in recent publications
A High-Throughput Fluorimetric Assay for 2-hydroxyglutarate Identifies Zaprinast as a Glutaminase Inhibitor Cancer Discov . April 2014 [IDH1]

ATM-mediated Mad1 Serine 214 phosphorylation regulates Mad1 dimerization and the spindle assembly checkpoint Carcinogenesis. April 2014 [anti-DDK]

Bromodomain and Extraterminal Proteins Suppress NF-E2-Related Factor 2-Mediated Antioxidant Gene Expression J. Immunol. April 2014 [Keap1]

Butyrate induced changes in Wnt-signaling specific gene expression in colorectal cancer cells BMC Res Notes 226 7 1. April 2014 [anti-DDK]

View All Citations >>
Home Gene of the month HES1

HES1 – Transcriptional Regulator

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HES1, hairy and enhancer of split 1, belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. HES1 is a key developmental gene that is overexpressed in certain cancers and is a primary target of Notch signaling. Notch and hedgehog pathways, which are frequently upregulated in tumors, lead to elevated HES1 levels. Studies of HES1 would lead to better understanding of the relationship between quiescent and cancer cells.

OriGene offers various antibodies against HES1:

  • TA500114 has been validated extensively with IHC staining
HES1 Fig2
IHC staining of paraffin-embedded endometrium using anti-HES1

OriGene products of HES1:

  1. ORF clones of human HES1 untagged or tagged with Myc-DDK/GFP
  2. shRNA and siRNA to knockdown HES1 expression
  3. HES1 protein purified from human cell line

Reference:

  • L.Sang, et. al. Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. Trends Mol Med. (2010) Jan;16(1):17-26.

View all HES1 products offering from OriGene >>

 

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