OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right


OriGene Antibodies in recent publications
Antibody 1A4 with routine immunohistochemistry demonstrates high sensitivity for ALK rearrangement screening of Chinese lung adenocarcinoma patients: A single-center large-scale study Lung Cancer May 2016 [ALK]

A screen of breast and colon cancers with HER2 antibody clone UMAB36 does not exhibit the cross-reactivity of clone 4B5 with HER4 protein AACR 2016 Abstract [HER2]

Evaluation of LGR5 protein expression in colon cancer stem cells AACR 2016 Abstract [LGR5]

Nano-fibrin stabilized CaSO4 crystals incorporated injectable chitin composite hydrogel for enhanced angiogenesis & osteogenesis Carbohydrate Polymers Apr2016 [SPP1]

View All Citations >>
Home Gene of the month HES1

HES1 – Transcriptional Regulator

divider

HES1, hairy and enhancer of split 1, belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. HES1 is a key developmental gene that is overexpressed in certain cancers and is a primary target of Notch signaling. Notch and hedgehog pathways, which are frequently upregulated in tumors, lead to elevated HES1 levels. Studies of HES1 would lead to better understanding of the relationship between quiescent and cancer cells.

OriGene offers various antibodies against HES1:

  • TA500114 has been validated extensively with IHC staining
HES1 Fig2
IHC staining of paraffin-embedded endometrium using anti-HES1

OriGene products of HES1:

  1. ORF clones of human HES1 untagged or tagged with Myc-DDK/GFP
  2. shRNA and siRNA to knockdown HES1 expression
  3. HES1 protein purified from human cell line

Reference:

  • L.Sang, et. al. Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. Trends Mol Med. (2010) Jan;16(1):17-26.

View all HES1 products offering from OriGene >>

 

patterns
Inc 5000 Healthcare Company
All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title