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OriGene Antibodies in recent publications
Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancer Oncol Lett 2016 [TP53]

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A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells Toxicol. Appl. Pharmacol. 2016 [DDK]

Aging asymmetry: systematic survey of changes in age-related biomarkers in the annual fish Nothobranchius guentheri Fish Physiol. Biochem. 2016 [ERCC1]

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Home Gene of the month HES1

HES1 – Transcriptional Regulator

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HES1, hairy and enhancer of split 1, belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. HES1 is a key developmental gene that is overexpressed in certain cancers and is a primary target of Notch signaling. Notch and hedgehog pathways, which are frequently upregulated in tumors, lead to elevated HES1 levels. Studies of HES1 would lead to better understanding of the relationship between quiescent and cancer cells.

OriGene offers various antibodies against HES1:

  • TA500114 has been validated extensively with IHC staining
HES1 Fig2
IHC staining of paraffin-embedded endometrium using anti-HES1

OriGene products of HES1:

  1. ORF clones of human HES1 untagged or tagged with Myc-DDK/GFP
  2. shRNA and siRNA to knockdown HES1 expression
  3. HES1 protein purified from human cell line

Reference:

  • L.Sang, et. al. Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. Trends Mol Med. (2010) Jan;16(1):17-26.

View all HES1 products offering from OriGene >>

 

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