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OriGene Antibodies in recent publications
Regulation of SREBP-2 intracellular trafficking improves impaired autophagic flux and alleviates endoplasmic reticulum stress in NAFLD Biochim. Biophys. Acta 2017 [Beclin1]

Viral Vector Reprogramming of Adult Resident Striatal Oligodendrocytes into Functional Neurons Molecular Therapy 2017 [DDK]

A Somatic HIF2α Mutation-Induced Multiple and Recurrent Pheochromocytoma/Paraganglioma with Polycythemia: Clinical Study with Literature Review Endocr. Pathol 2017 [VEGF]

Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes Sci Rep 2017 [CYP2A6]

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Home Gene of the month HES1

HES1 – Transcriptional Regulator

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HES1, hairy and enhancer of split 1, belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. HES1 is a key developmental gene that is overexpressed in certain cancers and is a primary target of Notch signaling. Notch and hedgehog pathways, which are frequently upregulated in tumors, lead to elevated HES1 levels. Studies of HES1 would lead to better understanding of the relationship between quiescent and cancer cells.

OriGene offers various antibodies against HES1:

  • TA500114 has been validated extensively with IHC staining
HES1 Fig2
IHC staining of paraffin-embedded endometrium using anti-HES1

OriGene products of HES1:

  1. ORF clones of human HES1 untagged or tagged with Myc-DDK/GFP
  2. shRNA and siRNA to knockdown HES1 expression
  3. HES1 protein purified from human cell line

Reference:

  • L.Sang, et. al. Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. Trends Mol Med. (2010) Jan;16(1):17-26.

View all HES1 products offering from OriGene >>

 

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