OriGene Technologies, Inc.
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right


OriGene Antibodies in recent publications
Extraordinary response to crizotinib in a woman with squamous cell lung cancer after two courses of failed chemotherapy BMC Pulm Med Jun 2014 []

A novel protein is lower expressed in renal cell carcinoma Int J Mol Sci May 2014 []

Aberrantly Over-Expressed TRPM8 Channels in Pancreatic Adenocarcinoma: Correlation with Tumor Size/Stage and Requirement for Cancer Cells Invasion Cells May 2014 []

An Aberrant Leukotriene A4 Hydrolase-PGP Pathway in the Pathogenesis of Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med. May 2014 []

View All Citations >>
Home Gene of the month HES1

HES1 – Transcriptional Regulator

divider

HES1, hairy and enhancer of split 1, belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. HES1 is a key developmental gene that is overexpressed in certain cancers and is a primary target of Notch signaling. Notch and hedgehog pathways, which are frequently upregulated in tumors, lead to elevated HES1 levels. Studies of HES1 would lead to better understanding of the relationship between quiescent and cancer cells.

OriGene offers various antibodies against HES1:

  • TA500114 has been validated extensively with IHC staining
HES1 Fig2
IHC staining of paraffin-embedded endometrium using anti-HES1

OriGene products of HES1:

  1. ORF clones of human HES1 untagged or tagged with Myc-DDK/GFP
  2. shRNA and siRNA to knockdown HES1 expression
  3. HES1 protein purified from human cell line

Reference:

  • L.Sang, et. al. Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. Trends Mol Med. (2010) Jan;16(1):17-26.

View all HES1 products offering from OriGene >>

 

patterns
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title