OriGene Antibodies in recent publications
Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL Mol. Cell. Neurosci., Feb 2014.
A PAI-1 mutant retards diabetic nephropathy in db/db mice through protecting podocytes Exp. Physiol., Jan 2014.
A Colon Cancer-Derived Mutant of Kruppel-Like Factor 5 (KLF5) Is Resistant to Degradation by Glycogen Synthase Kinase 3Î² (GSK3Î²) and the E3 Ubiquitin Ligase F-box and WD Repeat Domain-Containing 7Î± (FBW7Î±) J. Biol. Chem., Jan 2014.
[custom KLF5] |
Alteration of Bax/Bcl-2 ratio contributes to Terminalia belerica-induced apoptosis in human lung and breast carcinoma In Vitro Cell. Dev. Biol. Anim., Jan 2014.
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Home Gene of the month HES1|
HES1 – Transcriptional Regulator
HES1, hairy and enhancer of split 1, belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. HES1 is a key developmental gene that is overexpressed in certain cancers and is a primary target of Notch signaling. Notch and hedgehog pathways, which are frequently upregulated in tumors, lead to elevated HES1 levels. Studies of HES1 would lead to better understanding of the relationship between quiescent and cancer cells.
OriGene offers various antibodies against HES1:
- TA500114 has been validated extensively with IHC staining
|IHC staining of paraffin-embedded endometrium using anti-HES1
OriGene products of HES1:
- ORF clones of human HES1 untagged or tagged with Myc-DDK/GFP
- shRNA and siRNA to knockdown HES1 expression
- HES1 protein purified from human cell line
- L.Sang, et. al. Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. Trends Mol Med. (2010) Jan;16(1):17-26.
View all HES1 products offering from OriGene >>