OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right


OriGene Antibodies in recent publications
Activation of gill Ca2+-sensing receptor as a protective pathway to reduce Ca2+-induced cytotoxicity J. Mol. Endocrinol. Oct 2014 [STC1]

Aging Delays Resolution of Acute Inflammation in Mice: Reprogramming the Host Response with Novel Nanoproresolving Medicines J. Immunol. Sep 2014 [Alox15]

Decreased SIRT3 in aged human mesenchymal stromal/stem cells increases cellular susceptibility to oxidative stress J. Cell. Mol. Med. Sep 2014 [SOD2]

GADD45? induces G2/M arrest in human pharynx and nasopharyngeal carcinoma cells by cucurbitacin E Sci Rep Sep 2014 [GADD45G]

View All Citations >>
Home Gene of the month ERG

ERG Is A Prostate Cancer Biomarker

divider

The TMPRSS2-ERG gene rearrangements are commonly present in prostate cancer. Over-expression of ERG has also been considered as a specific prostate cancer biomarker which is rarely found in other cancers or normal tissues. Compared against current prostate cancer biomarkers, such as serum PSA level, which are often inadequate to accurately predict disease progression, early detection of TMPRSS2-ERG fusion gene, or simply detection of ERG over-expression would provide a significant diagnostic and prognostic value. See reference publication below.

Current methods to detecting TMPRSS2-ERG gene fusion include FISH assay, sequencing, qPCR assay and IHC. OriGene has developed a powerful tool for detecting ERG over-expression using TissueScan™ Tissue cDNA Arrays which contain panels of first strand cDNAs converted from RNA from cancer and normal tissues. This unique qPCR platform allows gene expression survey in hundreds’ cancer tissues within hours. Using our Cancer Survey cDNA Array (Cat# CSRT102) which contains 384 different samples of different cancer types including prostate cancer, our results demonstrate that only prostate cancer (40% of total tested prostate cancer samples) but not other cancer types or normal tissues shows up to 50-fold increase of ERG expression (see attached Fig.), supporting ERG overexpression is a prostate cancer specific phenomenon and could be provided as a specific marker for identifying aggressive prostate cancer subtype and guiding for proper treatment.

QPCR-prostate2

Citation:

TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort. By MA Rubin et al. Oncogene (2007) 26, 4596–4599.

OriGene Products for ERG:

  1. TissueScan Tissue cDNA Arrays for gene expression in prostate and other cancer tissues
  2. ERG gene specific full-length cDNA clones, recombinant proteins, shRNA, and antibodies

 

patterns
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title