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Home CRISPR-CAS9 KN318644

Ucma - mouse gene knockout kit via CRISPR

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Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN318644 Ucma - mouse gene knockout kit via CRISPR $1200 4 weeks Manual PDF Add to Shopping Cart
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Also for 1110017I16Rik (Locus ID 68527)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Request Antibody Service
SKU Description Donor Vector Price Availability  
KN318644RB Ucma - mouse gene knockout kit via CRISPR RFP-BSD 1290 4 weeks
KN318644LP Ucma - mouse gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN318644BN Ucma - mouse gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
Add to Shopping Cart

Comparing to KN318644, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
kn_donor_diagram
Kit Components
KN318644G1, 1110017I16Rik gRNA vector 1 in pCas-Guide vector
KN318644G2, 1110017I16Rik gRNA vector 2 in pCas-Guide vector
KN318644D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
   
GE100003, scramble sequence in pCas-Guide vector

Disclaimer
The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: BC115608BC115609NM_001113558NM_001165932NM_001311208NM_026754
Synonyms:
Summary: This gene encodes chondrocyte-specific, highly charged proteins that are abundantly expressed during the early stages of chondrogenesis. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Despite the implied role in calcification and ossification, mice lacking the encoded protein do not display significant defects in the skeletal development. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo a similar proteolytic processing to generate mature proteins. [provided by RefSeq, Aug 2015].

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Diagram-Gene Editing RecombII


 

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