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Home CRISPR-CAS9 KN300845

Adam8 - mouse gene knockout kit via CRISPR


Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN300845 Adam8 - mouse gene knockout kit via CRISPR $1200 4 weeks Manual PDF Add to Shopping Cart
Also for Adam8 (Locus ID 11501)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Request Antibody
SKU Description Donor Vector Price Availability  
KN300845RB Adam8 - mouse gene knockout kit via CRISPR RFP-BSD 1290 4 weeks
KN300845LP Adam8 - mouse gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN300845BN Adam8 - mouse gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
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Comparing to KN300845, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
Kit Components
KN300845G1, Adam8 gRNA vector 1 in pCas-Guide vector
KN300845G2, Adam8 gRNA vector 2 in pCas-Guide vector
KN300845D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector

The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: BC025584NM_001291066NM_007403
Synonyms: ADAM 8; CD156; CD156a; E430039A18Rik; MS2
Summary: This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extracellular matrix and cell migration. Mice lacking the encoded protein display persistent inflammation upon treatment with allergens. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015].

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