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Home CRISPR-CAS9 KN300536

a - mouse gene knockout kit via CRISPR

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Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN300536 a - mouse gene knockout kit via CRISPR $1200 4 weeks Manual PDF Add to Shopping Cart
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SKU Description Donor Vector Price Availability  
KN300536RB a - mouse gene knockout kit via CRISPR RFP-BSD 1290 4 weeks
KN300536LP a - mouse gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN300536BN a - mouse gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
Add to Shopping Cart

Comparing to KN300536, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
kn_donor_diagram
Kit Components
KN300536G1, a gRNA vector 1 in pCas-Guide vector
KN300536G2, a gRNA vector 2 in pCas-Guide vector
KN300536D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
   
GE100003, scramble sequence in pCas-Guide vector

Disclaimer
The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: BC009122NM_015770
Synonyms: A; As; ASIP; ASP
Summary: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth. [UniProtKB/Swiss-Prot Function]

Learn more about CRISPR?

Diagram-Gene Editing RecombII


 

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