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Home CRISPR-CAS9 KN221733

CACNA1E - human gene knockout kit via CRISPR

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Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN221733 CACNA1E - human gene knockout kit via CRISPR $1200 4 Weeks Manual PDF Add to Shopping Cart
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Also for CACNA1E (Locus ID 777)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Request Antibody
SKU Description Donor Vector Price Availability  
KN221733RB CACNA1E - human gene knockout kit via CRISPR RFP-BSD 1290 4 Weeks
KN221733LP CACNA1E - human gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN221733BN CACNA1E - human gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
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Comparing to KN221733, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
kn_donor_diagram
Kit Components
KN221733G1, CACNA1E gRNA vector 1 in pCas-Guide vector
KN221733G2, CACNA1E gRNA vector 2 in pCas-Guide vector
KN221733D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
   
GE100003, scramble sequence in pCas-Guide vector

Disclaimer
The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: NM_000721NM_001205293NM_001205294XM_017002243XM_017002244XM_017002245XM_017002246XM_017002247XM_017002248XM_017002249XM_017002250XM_017002251XM_099551
Synonyms: BII; CACH6; CACNL1A6; Cav2.3
Summary: Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011].

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Diagram-Gene Editing RecombII


 

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