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Home CRISPR-CAS9 KN219186

UNC13B - human gene knockout kit via CRISPR

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Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN219186 UNC13B - human gene knockout kit via CRISPR $1200 4 Weeks Manual PDF Add to Shopping Cart
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Also for UNC13B (Locus ID 10497)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Request Antibody
SKU Description Donor Vector Price Availability  
KN219186RB UNC13B - human gene knockout kit via CRISPR RFP-BSD 1290 4 Weeks
KN219186LP UNC13B - human gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN219186BN UNC13B - human gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
Add to Shopping Cart

Comparing to KN219186, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
kn_donor_diagram
Kit Components
KN219186G1, UNC13B gRNA vector 1 in pCas-Guide vector
KN219186G2, UNC13B gRNA vector 2 in pCas-Guide vector
KN219186D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
   
GE100003, scramble sequence in pCas-Guide vector

Disclaimer
The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: NM_006377XM_011517681XM_011517682XM_011517683XM_011517685XM_011517686XM_017014191XM_017014192
Synonyms: MUNC13; UNC13; Unc13h2
Summary: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]

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Diagram-Gene Editing RecombII


 

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