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Home CRISPR-CAS9 KN217698

NCOA6 - human gene knockout kit via CRISPR

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Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN217698 NCOA6 - human gene knockout kit via CRISPR $1200 4 Weeks Manual PDF Add to Shopping Cart
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SKU Description Donor Vector Price Availability  
KN217698RB NCOA6 - human gene knockout kit via CRISPR RFP-BSD 1290 4 Weeks
KN217698LP NCOA6 - human gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN217698BN NCOA6 - human gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
Add to Shopping Cart

Comparing to KN217698, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
kn_donor_diagram
Kit Components
KN217698G1, NCOA6 gRNA vector 1 in pCas-Guide vector
KN217698G2, NCOA6 gRNA vector 2 in pCas-Guide vector
KN217698D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
   
GE100003, scramble sequence in pCas-Guide vector

Disclaimer
The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: NM_001242539NM_014071XM_006723755XM_011528721XM_011528726XM_011528727XM_017027739XM_017027740XM_017027741XM_017027742XM_017027743XM_017027744XM_017027745XM_017027746XM_017027747XM_017027748XM_017027749XM_017027750XM_017027751XR_001754214XR_001754215
Synonyms: AIB3; ASC2; NRC; PRIP; RAP250; TRBP
Summary: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. [UniProtKB/Swiss-Prot Function]

Learn more about CRISPR?

Diagram-Gene Editing RecombII


 

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