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Home CRISPR-CAS9 KN216831

SDHAF1 - human gene knockout kit via CRISPR

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Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN216831 SDHAF1 - human gene knockout kit via CRISPR $1200 4 Weeks Manual PDF Add to Shopping Cart
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Also for SDHAF1 (Locus ID 644096)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Request Antibody
SKU Description Donor Vector Price Availability  
KN216831RB SDHAF1 - human gene knockout kit via CRISPR RFP-BSD 1290 4 Weeks
KN216831LP SDHAF1 - human gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN216831BN SDHAF1 - human gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
Add to Shopping Cart

Comparing to KN216831, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
kn_donor_diagram
Kit Components
KN216831G1, SDHAF1 gRNA vector 1 in pCas-Guide vector
KN216831G2, SDHAF1 gRNA vector 2 in pCas-Guide vector
KN216831D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
   
GE100003, scramble sequence in pCas-Guide vector

Disclaimer
The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: NM_001042631
Synonyms: LYRM8; LYRM8
Summary: The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency).[provided by RefSeq, Mar 2010].

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Diagram-Gene Editing RecombII


 

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