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Home CRISPR-CAS9 KN203202

EEF1D - human gene knockout kit via CRISPR


Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN203202 EEF1D - human gene knockout kit via CRISPR $1200 4 Weeks Manual PDF Add to Shopping Cart
SKU Description Donor Vector Price Availability  
KN203202RB EEF1D - human gene knockout kit via CRISPR RFP-BSD 1290 4 Weeks
KN203202LP EEF1D - human gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN203202BN EEF1D - human gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
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Comparing to KN203202, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
Kit Components
KN203202G1, EEF1D gRNA vector 1 in pCas-Guide vector
KN203202G2, EEF1D gRNA vector 2 in pCas-Guide vector
KN203202D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector

The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: NM_001130053NM_001130054NM_001130055NM_001130056NM_001130057NM_001195203NM_001289950NM_001317743NM_001330646NM_001960NM_032378XM_005250820XM_005250823XM_006716519XM_006716520XM_006716522XM_006716523XM_006716524XM_006716525XM_011516905XM_011516906XM_017013168XM_017013169XM_017013170XM_017013171XM_017013172
Synonyms: EF-1D; EF1D; FLJ20897; FP1047; EF1D; FLJ20897; FP1047; antigen NY-CO-4; eukaryotic translation elongation factor 1 delta; guanine nucleotide exchange protein; eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Summary: This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010].

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