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Home CRISPR-CAS9 KN202182

NFKBIB - human gene knockout kit via CRISPR

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Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN202182 NFKBIB - human gene knockout kit via CRISPR $1200 4 Weeks Manual PDF Add to Shopping Cart
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Also for NFKBIB (Locus ID 4793)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Request Antibody
SKU Description Donor Vector Price Availability  
KN202182RB NFKBIB - human gene knockout kit via CRISPR RFP-BSD 1290 4 Weeks
KN202182LP NFKBIB - human gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN202182BN NFKBIB - human gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
Add to Shopping Cart

Comparing to KN202182, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
kn_donor_diagram
Kit Components
KN202182G1, NFKBIB gRNA vector 1 in pCas-Guide vector
KN202182G2, NFKBIB gRNA vector 2 in pCas-Guide vector
KN202182D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
   
GE100003, scramble sequence in pCas-Guide vector

Disclaimer
The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: NM_001001716NM_001243116NM_002503NR_040515XM_006723226XM_006723227
Synonyms: IKBB; TRIP9
Summary: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. [UniProtKB/Swiss-Prot Function]

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Diagram-Gene Editing RecombII


 

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