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Home CRISPR-CAS9 KN201993

GABRB3 - human gene knockout kit via CRISPR

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Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN201993 GABRB3 - human gene knockout kit via CRISPR $1200 4 Weeks Manual PDF Add to Shopping Cart
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Also for GABRB3 (Locus ID 2562)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Request Antibody
SKU Description Donor Vector Price Availability  
KN201993RB GABRB3 - human gene knockout kit via CRISPR RFP-BSD 1290 4 Weeks
KN201993LP GABRB3 - human gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN201993BN GABRB3 - human gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
Add to Shopping Cart

Comparing to KN201993, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
kn_donor_diagram
Kit Components
KN201993G1, GABRB3 gRNA vector 1 in pCas-Guide vector
KN201993G2, GABRB3 gRNA vector 2 in pCas-Guide vector
KN201993D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
   
GE100003, scramble sequence in pCas-Guide vector

Disclaimer
The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: NM_000814NM_001191320NM_001191321NM_001278631NM_021912NR_103801XM_011521428
Synonyms: ECA5; ECA5
Summary: This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013].

Learn more about CRISPR?

Diagram-Gene Editing RecombII


 

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