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Home CRISPR-CAS9 KN201872

ASCC1 - human gene knockout kit via CRISPR

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Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN201872 ASCC1 - human gene knockout kit via CRISPR $1200 4 Weeks Manual PDF Add to Shopping Cart
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Also for ASCC1 (Locus ID 51008)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Request Antibody
SKU Description Donor Vector Price Availability  
KN201872RB ASCC1 - human gene knockout kit via CRISPR RFP-BSD 1290 4 Weeks
KN201872LP ASCC1 - human gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN201872BN ASCC1 - human gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
Add to Shopping Cart

Comparing to KN201872, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
kn_donor_diagram
Kit Components
KN201872G1, ASCC1 gRNA vector 1 in pCas-Guide vector
KN201872G2, ASCC1 gRNA vector 2 in pCas-Guide vector
KN201872D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
   
GE100003, scramble sequence in pCas-Guide vector

Disclaimer
The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: BC012291NM_001198798NM_001198799NM_001198800NM_015947NR_045564XM_006717873XM_011539841XM_011539842XM_017016291XM_017016292XM_017016293XM_017016294XM_017016295XM_017016296XM_017016297XM_017016298XM_017016299XM_017016300XM_017016301XM_017016302XM_017016303
Synonyms: ASC1p50; CGI-18; p50
Summary: This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

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Diagram-Gene Editing RecombII


 

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