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Home CRISPR-CAS9 KN201268

PAFAH1B3 - human gene knockout kit via CRISPR

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Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN201268 PAFAH1B3 - human gene knockout kit via CRISPR $1200 4 Weeks Manual PDF Add to Shopping Cart
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Also for PAFAH1B3 (Locus ID 5050)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Request Antibody
SKU Description Donor Vector Price Availability  
KN201268RB PAFAH1B3 - human gene knockout kit via CRISPR RFP-BSD 1290 4 Weeks
KN201268LP PAFAH1B3 - human gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN201268BN PAFAH1B3 - human gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
Add to Shopping Cart

Comparing to KN201268, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
kn_donor_diagram
Kit Components
KN201268G1, PAFAH1B3 gRNA vector 1 in pCas-Guide vector
KN201268G2, PAFAH1B3 gRNA vector 2 in pCas-Guide vector
KN201268D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
   
GE100003, scramble sequence in pCas-Guide vector

Disclaimer
The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: NM_001145939NM_001145940NM_002573XM_017026846XM_017026847XM_017026848
Synonyms: PAFAHG
Summary: This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with mental retardation, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009].

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Diagram-Gene Editing RecombII


 

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