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Home Antibody All anti-Nog antibodies

Anti-Nog TRUEMAB Antibody clone 1C1

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA500116
  • anti-Noggin (Noggin) mouse monoclonal antibody, clone 1C1
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401672) , 20ug
100ul 325 In Stock
CF500116
  • Carrier-free (BSA/glycerol-free) Noggin mouse monoclonal antibody,clone 1C1
100ug $450 3-4 weeks
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WB(1)
IHC(8)
IF(1)
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Also for Nog (NM_005450)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant protein expressed in E.coli corresponding to amino acids 28-232 of human noggin
Clone Nameclone 1C1 IsotypeIgG2b
Species ReactivityHuman Concentration0.75mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:40000, IHC 1:50, IF (1:100)
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens noggin (NOG)
Alternative NameSYM1; SYNS1
Database LinkNP_005441
FunctionNoggin is a secreted polypeptide which binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, it may have a principal role in creating morphogenic gradients. Noggin appears to have pleiotropic effect, both early in development as well as in later stages. The results of the mouse knockout of the ortholog suggest that noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse
Related Pathway
TGF Beta Signaling Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Nog(RC205020) (RC205020, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-Nog.
IHC Image
Immunohistochemical staining of paraffin-embedded breast using anti-Nog (TA500116) mouse monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of colon using anti-Nog (TA500116) mouse monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded kidney using anti-Nog (TA500116) mouse monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of kidney using anti-Nog (TA500116) mouse monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of lung using anti-Nog (TA500116) mouse monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded pancreas using anti-Nog(TA500116) mouse monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded thyroid using anti-Nog(TA500116) mouse monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of thyroid using anti-Nog(TA500116) mouse monoclonal antibody.
IF Image
Anti-Nog mouse monoclonal antibody (TA500116) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY Nog(RC205020).

 

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