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Home Antibody All anti-SELK antibodies

Anti-SELK Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319992
  • Rabbit Polyclonal SELK Antibody
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenSELK antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SELK.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 - 2 ug/ml, IF: 20 ug/ml
BufferSELK Antibody is supplied in PBS containing 0.02% sodium azide.
Purification SELK Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens selenoprotein K (SELK)
Alternative NameHSPC030; HSPC297
Database LinkNP_067060
FunctionSELK Antibody: SELK is a selenoprotein, containing a selenocysteine residue at its active site. SELK is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. SELK can bind to proteins such as the ER-associated degradation (ERAD) components p97 ATPase, Derlin-1 and -2, and SelS as well as proteins in the oligosaccharyltransferase complex, suggesting that SELK may be involved in the Derlin-dependent ERAD of glycosylated misfolded proteins. SELK is also thought to be important in Ca2+ flux in immune cells, and is cleaved by m-calpain in resting macrophages. When these macrophages are activated through different Toll-like receptors, this cleavage is inhibited
Related Pathway

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WB Image
Western blot analysis of SELK in A20 cell lysate with SELK antibody at (A) 1 and (B) 2 ug/mL.
IF Image
Immunofluorescence of SELK in human heart tissue with SELK antibody at 20 ug/mL.

 

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